用于一氧化氮的高灵敏度近红外荧光探针及其在离体器官中的应用。
Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs.
作者信息
Sasaki Eita, Kojima Hirotatsu, Nishimatsu Hiroaki, Urano Yasuteru, Kikuchi Kazuya, Hirata Yasunobu, Nagano Tetsuo
机构信息
Graduate School of Pharmaceutical Sciences, and Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
J Am Chem Soc. 2005 Mar 23;127(11):3684-5. doi: 10.1021/ja042967z.
Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.
新型一氧化氮（NO）近红外（NIR）荧光探针已被设计、合成和评估。在生理条件下，它们的近红外荧光以NO浓度依赖性方式增强，并且它们与NO的反应效率比广泛使用的NO探针DAF-2至少高53倍。已证实它们在离体完整大鼠肾脏中发挥作用。由于近红外光可以深入穿透组织，这些探针可能具有体内NO成像的潜力。
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