ORF组规模上密码子对的比较背景分析。
Comparative context analysis of codon pairs on an ORFeome scale.
作者信息
Moura Gabriela, Pinheiro Miguel, Silva Raquel, Miranda Isabel, Afreixo Vera, Dias Gaspar, Freitas Adelaide, Oliveira José L, Santos Manuel A S
机构信息
Centre for Cell Biology, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
出版信息
Genome Biol. 2005;6(3):R28. doi: 10.1186/gb-2005-6-3-r28. Epub 2005 Feb 15.
Abstract
Codon context is an important feature of gene primary structure that modulates mRNA decoding accuracy. We have developed an analytical software package and a graphical interface for comparative codon context analysis of all the open reading frames in a genome (the ORFeome). Using the complete ORFeome sequences of Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida albicans and Escherichia coli, we show that this methodology permits large-scale codon context comparisons and provides new insight on the rules that govern the evolution of codon-pair context.
摘要
密码子上下文是基因一级结构的一个重要特征，它能调节mRNA解码的准确性。我们开发了一个分析软件包和一个图形界面，用于对基因组中的所有开放阅读框（ORFeome）进行密码子上下文比较分析。利用酿酒酵母、粟酒裂殖酵母、白色念珠菌和大肠杆菌的完整ORFeome序列，我们表明这种方法允许进行大规模的密码子上下文比较，并为支配密码子对上下文进化的规则提供了新的见解。
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