与食管癌相关基因的密码子使用偏好性分析

Codon usage bias analysis of genes linked with esophagus cancer.

作者信息

Bordoloi Hemashree, Nirmala S R

机构信息

Deptartment of Electronics and Communication Engineering, Gauhati University, Assam, Indi.

Department of Electronics and Communication Engineering, Assam Don Bosco University, Assam, India.

出版信息

Bioinformation. 2021 Aug 31;17(8):731-740. doi: 10.6026/97320630017731. eCollection 2021.

DOI:10.6026/97320630017731

PMID:35540696

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9049095/

Abstract

Esophageal cancer involves multiple genetic alternations. A systematic codon usage bias analysis was completed to investigate the bias among the esophageal cancer responsive genes. GC-rich genes were low (average effective number of codon value was 49.28). CAG and GTA are over-represented and under-represented codons, respectively. Correspondence analysis, neutrality plot, and parity rule 2 plot analysis confirmed the dominance over mutation pressure in modulating the codon usage pattern of genes linked with esophageal cancer.

摘要

食管癌涉及多种基因改变。为研究食管癌反应相关基因间的密码子使用偏好，我们完成了一项系统的密码子使用偏好性分析。富含GC的基因比例较低（密码子平均有效数量值为49.28）。CAG和GTA分别是使用过度和使用不足的密码子。对应分析、中性绘图和奇偶规则2绘图分析证实，在调节与食管癌相关基因的密码子使用模式方面，突变压力起主导作用。