Khandia Rekha, Pandey Megha Katare, Khan Azmat Ali, Rzhepakovsky Igor Vladimirovich, Gurjar Pankaj, Karobari Mohmed Isaqali
Department of Biochemistry and Genetics, Barkatullah University, Bhopal 462026, India.
Department of Translational Medicine, All India Institute of Medical Sciences, Bhopal 462020, India.
Vaccines (Basel). 2022 Nov 6;10(11):1874. doi: 10.3390/vaccines10111874.
The overexpression of SARS-CoV-2 primary receptors and co-receptors (, , , and ) enhance the likeliness of SARS-CoV-2 infection. The genes for same receptors are overexpressed in the periodontal tissues of periodontitis patients. On the other hand, is recognized to play a crucial role in regulating pulmonary inflammation and enhancing susceptibility to viral infection. Silenced disrupts circadian transcriptional regulations, enhances vulnerability to SARS-CoV-2 infections, and may trigger the further production of TNF-α and other pro-inflammatory cytokines that propagate the cytokine storm and exacerbate periodontal inflammation. Therefore , , , , and are the crossroads between SARS-CoV-2 and Periodontitis genes. The enhanced expression of , , , and and the diminished expression of may be a strategy to check both ailments simultaneously. In gene manipulation techniques, oligos are introduced, which contain all the necessary information to manipulate gene expression. The data are derived from the studies on genes' molecular patterns, including nucleotide composition, dinucleotide patterns, relative synonymous codon usage, codon usage bias, codon context, and rare and abundant codons. Such information may be used to manipulate the overexpression and underexpression of the genes at the time of SARS-CoV-2 infection and periodontitis to mitigate both ailments simultaneously; it can be explored to uncover possible future treatments.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）主要受体和共受体（ 、 、 和 ）的过表达增加了SARS-CoV-2感染的可能性。牙周炎患者牙周组织中相同受体的基因过表达。另一方面， 被认为在调节肺部炎症和增加病毒感染易感性方面起关键作用。沉默 会破坏昼夜节律转录调控，增加对SARS-CoV-2感染的易感性，并可能引发肿瘤坏死因子-α（TNF-α）和其他促炎细胞因子的进一步产生，从而引发细胞因子风暴并加重牙周炎症。因此， 、 、 、 和 是SARS-CoV-2与牙周炎基因之间的交叉点。 、 、 和 的表达增强以及 的表达减弱可能是同时控制这两种疾病的一种策略。在基因操作技术中，引入了寡核苷酸，其包含操纵基因表达所需的所有信息。数据来自对基因分子模式的研究，包括核苷酸组成、二核苷酸模式、相对同义密码子使用、密码子使用偏好、密码子上下文以及稀有和丰富密码子。此类信息可用于在SARS-CoV-2感染和牙周炎时操纵基因的过表达和低表达，以同时减轻这两种疾病；可探索利用这些信息来发现未来可能的治疗方法。
