Maschke M, Tuite P J, Pickett K, Wächter T, Konczak J
Sensorimotor Control Laboratory, Division of Kinesiology, University of Minnesota, Minneapolis, MN, USA.
J Neurol Neurosurg Psychiatry. 2005 Apr;76(4):569-71. doi: 10.1136/jnnp.2004.047324.
Parkinson's disease is accompanied by deficits in passive motion and limb position sense.
To investigate whether deep brain stimulation of the subthalamic nucleus (STN-DBS) reverses these proprioceptive deficits.
A passive movement task was applied to nine patients with Parkinson's disease and bilateral chronic STN-DBS and to seven controls. Thresholds for 75% correct responses were 0.9 degrees for controls, 2.5 degrees for Parkinson's disease patients when stimulation was OFF, and 2.0 degrees when stimulation was ON.
STN-DBS improves kinaesthesic deficits in Parkinson's disease, but does not lead to a full recovery of proprioceptive function.
帕金森病伴有被动运动和肢体位置觉缺陷。
研究丘脑底核深部脑刺激(STN-DBS)是否能逆转这些本体感觉缺陷。
对9例患有帕金森病且接受双侧慢性STN-DBS治疗的患者以及7名对照者进行了被动运动任务。对照组75%正确反应的阈值为0.9度,帕金森病患者在刺激关闭时为2.5度,刺激开启时为2.0度。
STN-DBS可改善帕金森病的动觉缺陷,但不能使本体感觉功能完全恢复。