Niu L, Ji L-Y, Li J-M, Zhao D-S, Huang G, Liu W-P, Qu Y, Ma L-T, Ji X-T
Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
J Int Med Res. 2012;40(3):1108-13. doi: 10.1177/147323001204000330.
A prospective cohort study to evaluate the efficacy of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on freezing of gait (FOG) in patients with advanced Parkinson's disease.
Patients (n = 10) with advanced Parkinson's disease were surgically implanted with microelectrodes to facilitate STN-DBS. Evaluations of FOG, motor function, activities of daily living and neuropsychological function were carried out in on-medication and off-medication states (with and without levodopa treatment), before surgery and at 6 and 12 months postoperatively.
STN-DBS was associated with significant improvement in FOG score and neuropsychological function at both 6 and 12 months postoperatively, compared with preoperatively. Significant postoperative improvements were also observed in motor function and activities of daily living. Daily levodopa dosage was significantly lower at both 6 and 12 months postoperatively.
STN-DBS improved FOG in patients with advanced Parkinson's disease. The significant reduction in levodopa dosage and improvement in neuropsychological function may be the reason for the therapeutic effect seen with STN-DBS.
一项前瞻性队列研究，旨在评估双侧丘脑底核深部脑刺激（STN-DBS）对晚期帕金森病患者步态冻结（FOG）的疗效。
对10例晚期帕金森病患者进行手术植入微电极以实施STN-DBS。在术前、术后6个月和12个月时，分别在服药和停药状态（使用和不使用左旋多巴治疗）下对患者的步态冻结、运动功能、日常生活活动能力和神经心理功能进行评估。
与术前相比，术后6个月和12个月时，STN-DBS均与步态冻结评分和神经心理功能的显著改善相关。术后运动功能和日常生活活动能力也有显著改善。术后6个月和12个月时，每日左旋多巴剂量均显著降低。
STN-DBS改善了晚期帕金森病患者的步态冻结。左旋多巴剂量的显著降低和神经心理功能的改善可能是STN-DBS产生治疗效果的原因。
