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俯卧位猪的局部低氧性肺血管收缩

Regional hypoxic pulmonary vasoconstriction in prone pigs.

作者信息

Starr I R, Lamm W J E, Neradilek B, Polissar N, Glenny R W, Hlastala M P

机构信息

Department of Medicine, Univ. of Washington, Seattle, WA, USA.

出版信息

J Appl Physiol (1985). 2005 Jul;99(1):363-70. doi: 10.1152/japplphysiol.00822.2004. Epub 2005 Mar 17.

Abstract

Hypoxic pulmonary vasoconstriction (HPV) is known to affect regional pulmonary blood flow distribution. It is unknown whether lungs with well-matched ventilation (V)/perfusion (Q) have regional differences in the HPV response. Five prone pigs were anesthetized and mechanically ventilated (positive end-expiratory pressure = 2 cmH2O). Two hypoxic preconditions [inspired oxygen fraction (FI(O2)) = 0.13] were completed to stabilize the animal's hypoxic response. Regional pulmonary blood Q and V distribution was determined at various FI(O2) (0.21, 0.15, 0.13, 0.11, 0.09) using the fluorescent microsphere technique. Q and V in the lungs were quantified within 2-cm3 lung pieces. Pieces were grouped, or clustered, based on the changes in blood flow when subjected to increasing hypoxia. Unique patterns of Q response to hypoxia were seen within and across animals. The three main patterns (clusters) showed little initial difference in V/Q matching at room air where the mean V/Q range was 0.92-1.06. The clusters were spatially located in cranial, central, and caudal portions of the lung. With decreasing FI(O2), blood flow shifted from the cranial to caudal regions. We determined that pulmonary blood flow changes, caused by HPV, produced distinct response patterns that were seen in similar regions across our prone porcine model.

摘要

已知低氧性肺血管收缩(HPV)会影响局部肺血流分布。通气(V)/灌注(Q)匹配良好的肺在HPV反应中是否存在区域差异尚不清楚。对五头俯卧位猪进行麻醉并机械通气(呼气末正压 = 2 cmH2O)。完成两个低氧预处理 [吸入氧分数(FI(O2))= 0.13] 以稳定动物的低氧反应。使用荧光微球技术在不同的FI(O2)(0.21、0.15、0.13、0.11、0.09)下测定局部肺血流Q和V分布。在2 cm3的肺组织块中对肺内的Q和V进行定量。根据缺氧程度增加时血流的变化将组织块分组或聚类。在动物个体内和个体间观察到对缺氧的Q反应的独特模式。三种主要模式(聚类)在室内空气中V/Q匹配方面最初差异不大,平均V/Q范围为0.92 - 1.06。这些聚类在空间上位于肺的头侧、中央和尾侧部分。随着FI(O2)降低,血流从头侧区域转移到尾侧区域。我们确定,由HPV引起的肺血流变化产生了不同的反应模式,在我们的俯卧位猪模型的相似区域中可以观察到。

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