Kubota K, Ishiwata K, Yamada S, Kubota R, Sato T, Takahashi J, Ito H, Ido T, Tada M
Department of Radiology, Tohoku University, Sendai, Japan.
Int J Rad Appl Instrum B. 1992 Jan;19(1):27-32. doi: 10.1016/0883-2897(92)90181-w.
The L-[methyl-11C]methionine [( 11C]Met) uptake by rat AH109A tumor was decreased irradiation-dose dependently from the control to 5, 10 and 20 Gy. After 10 Gy irradiation, the [11C]Met uptake decreased earlier than the tumor volume reduction, and later, it significantly increased earlier than the recurrent growth. Double tracer autoradiography with [14C]Met and 4-[18F]fluoroantipyrine showed a decrease in the [14C]Met tumor uptake without change of blood flow after irradiation. The [11C]Met uptake representing amino acid metabolism is a sensitive indicator for monitoring radiotherapeutic effect on tumor.
大鼠AH109A肿瘤对L-[甲基-11C]蛋氨酸([11C]Met)的摄取量随照射剂量的增加而降低，从对照组到5、10和20 Gy剂量组均如此。照射10 Gy后，[11C]Met摄取量的降低早于肿瘤体积的缩小，随后，其显著增加又早于肿瘤复发生长。用[14C]Met和4-[18F]氟安替比林进行的双示踪剂放射自显影显示，照射后肿瘤对[14C]Met的摄取减少，而血流量无变化。代表氨基酸代谢的[11C]Met摄取量是监测放疗对肿瘤疗效的敏感指标。
