Kubota K, Matsuzawa T, Takahashi T, Fujiwara T, Kinomura S, Ido T, Sato T, Kubota R, Tada M, Ishiwata K
Department of Radiology and Nuclear Medicine, Tohoku University, Japan.
J Nucl Med. 1989 Dec;30(12):2012-6.
Evaluation of cancer treatments by the measurement of tumor size is an unsatisfactory method for the observation of the radiobiologic response of the tumor. After 20 Gy single-dose irradiation of 60Co to rat tumor AH109A, the L-[methyl-11C] methionine tumor uptake, the microscopic extension of tumor necrosis and the shrinkage of tumor were compared quantitatively. L-[Methyl-11C]methionine uptake fell to 54 +/- 19% of non irradiated tumor at 12 hr after irradiation. Necrosis extended 49 +/- 7% of total tissue volume after 3 days. Tumor volume decreased 48 +/- 12% 10 days after irradiation. L-[Methyl-11C]methionine uptake by tumor showed a sharp and rapid linear decrease after irradiation and the response of the uptake to irradiation preceded the extension of necrosis and tumor shrinkage. We conclude that radiation effect on the tumor may be evaluated immediately after irradiation by the measurement of L-[methyl-11C]methionine uptake and thus clinical application of positron emission tomography may give a benefit to the patients undergoing radiotherapy.
通过测量肿瘤大小来评估癌症治疗效果，对于观察肿瘤的放射生物学反应而言是一种不尽人意的方法。对大鼠肿瘤AH109A进行60Co单剂量20 Gy照射后，对L-[甲基-11C]蛋氨酸的肿瘤摄取、肿瘤坏死的微观扩展以及肿瘤的缩小进行了定量比较。照射后12小时，L-[甲基-11C]蛋氨酸摄取降至未照射肿瘤的54±19%。3天后，坏死扩展至总组织体积的49±7%。照射10天后，肿瘤体积减小48±12%。照射后肿瘤对L-[甲基-11C]蛋氨酸的摄取呈急剧且快速的线性下降，摄取对照射的反应先于坏死扩展和肿瘤缩小。我们得出结论，通过测量L-[甲基-11C]蛋氨酸摄取可在照射后立即评估辐射对肿瘤的影响，因此正电子发射断层扫描的临床应用可能会使接受放射治疗的患者受益。
