即使在没有斑块的情况下，中风的发生率也与颈动脉内膜中层厚度有关。
Incidence of stroke is related to carotid IMT even in the absence of plaque.
作者信息
Rosvall M, Janzon L, Berglund G, Engström G, Hedblad B
机构信息
Department of Community Medicine, Lund University, Malmö University Hospital, SE-205 02 Malmö, Sweden.
出版信息
Atherosclerosis. 2005 Apr;179(2):325-31. doi: 10.1016/j.atherosclerosis.2004.10.015. Epub 2004 Dec 8.
BACKGROUND
The carotid intima-media thickness (IMT) has been associated with incidence of stroke. Whether this association is independent of carotid plaque is controversial.
METHODS AND RESULTS
The associations among B-mode ultrasound determined common carotid IMT, carotid plaque (focal IMT>1.2mm) and incident stroke, were investigated in 5163 Swedish middle-aged men and women over a median follow-up of 7 years. Age and sex-adjusted carotid IMT, and carotid plaque were significantly (p<0.05) related to future stroke. Adjustment for cardiovascular risk factors generally reduced the hazard rate ratios, however more prominently so with regard to the carotid measure of plaque than with IMT. The associations between carotid IMT and stroke remained after adjustment for presence of carotid plaque, and graded associations between carotid IMT and stroke was found both among those with and without carotid plaque.
CONCLUSIONS
In this population-based study, common carotid IMT was associated with incidence of stroke. This relation was independent of presence of carotid plaque.
背景
颈动脉内膜中层厚度（IMT）与中风发病率相关。这种关联是否独立于颈动脉斑块存在争议。
方法与结果
对5163名瑞典中年男性和女性进行了研究，通过B超测定颈总动脉IMT、颈动脉斑块（局部IMT>1.2mm）与中风发生率之间的关联，中位随访时间为7年。经年龄和性别调整后的颈动脉IMT以及颈动脉斑块与未来中风显著相关（p<0.05）。对心血管危险因素进行调整后，危险率比值通常会降低，不过颈动脉斑块指标的降低更为显著，而IMT的降低则不那么明显。在调整了颈动脉斑块的存在情况后，颈动脉IMT与中风之间的关联依然存在，并且在有和没有颈动脉斑块的人群中均发现了颈动脉IMT与中风之间的分级关联。
结论
在这项基于人群的研究中，颈总动脉IMT与中风发生率相关。这种关系独立于颈动脉斑块的存在。
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