黏多糖的选择性暴露参与巨噬细胞生理过程。

Selective exposure of mucopolysaccharides is involved in macrophage physiology.

作者信息

Del Rosso M, Cappelletti R, Vannucchi S, Romagnani S, Chiarugi V P

出版信息

Biochim Biophys Acta. 1979 Sep 3;586(3):512-17. doi: 10.1016/0304-4165(79)90041-2.

Abstract

Surface and intracellular mucopolysaccharides of guinea-pig peritoneal macrophages maintained in suspension and monolayer culture were studied. At least five classes of compound (hyaluronic acid, heparan sulfate, dermatan sulfate, chondroitin 4-sulfate and chondroitin 6-sulfate) were resolved and characterized by electrophoresis and enzymatic degradation. The results reported here suggest that modulation of mucopolysaccharide exposure is involved in macrophage physiology. The possible biological role of surface mucopolysaccharides in macrophage activity is discussed.

摘要

对悬浮培养和单层培养的豚鼠腹膜巨噬细胞的表面及细胞内黏多糖进行了研究。通过电泳和酶降解解析并鉴定了至少五类化合物（透明质酸、硫酸乙酰肝素、硫酸皮肤素、硫酸软骨素4和硫酸软骨素6）。本文报道的结果表明，黏多糖暴露的调节参与巨噬细胞生理过程。讨论了表面黏多糖在巨噬细胞活性中的可能生物学作用。