Usonis V, Meriste S, Bakasenas V, Lutsar I, Collard F, Stoffel M, Tornieporth N
Centre of Paediatrics, Vilnius University, P.O. Box 2561, 2009 Vilnius, Lithuania.
Vaccine. 2005 Apr 8;23(20):2602-6. doi: 10.1016/j.vaccine.2004.11.062.
Two studies were undertaken to investigate the concomitant administration of combined hepatitis A/B vaccine with a diphtheria-tetanus-acellular pertussis-inactivated poliomyelitis vaccine mixed with Haemophilus influenzae vaccine (DTPa-IPV/Hib), or with a measles-mumps-rubella vaccine (MMR), during the second year of life. On completion of the vaccination course, all subjects were seropositive or seroprotected against all antigens except for one subject who was seronegative for anti-PT. Seropositivity and seroprotection rates for all other antibodies were comparable to reference values for each vaccine component, indicating that the immunogenicity of MMR, DTPa-IPV/Hib and combined hepatitis A/B vaccines is not impaired by co-administration. All vaccines were well tolerated.
开展了两项研究，以调查在生命的第二年，将甲型/乙型肝炎联合疫苗与白喉-破伤风-无细胞百日咳-灭活脊髓灰质炎疫苗混合流感嗜血杆菌疫苗（DTPa-IPV/Hib）或麻疹-腮腺炎-风疹疫苗（MMR）同时接种的情况。在完成疫苗接种疗程后，除一名受试者抗百日咳毒素呈血清阴性外，所有受试者对所有抗原均呈血清阳性或血清保护状态。所有其他抗体的血清阳性率和血清保护率与每种疫苗成分的参考值相当，这表明同时接种MMR、DTPa-IPV/Hib和甲型/乙型肝炎联合疫苗不会损害其免疫原性。所有疫苗的耐受性良好。
