Woodgett James R
Ontario Cancer Institute/Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario M5G 2 M9, Canada.
Curr Opin Cell Biol. 2005 Apr;17(2):150-7. doi: 10.1016/j.ceb.2005.02.010.
The phosphoinositide 3' kinase signaling pathway is activated in response to a plethora of growth factors and cytokines, and initiates a cascade of signaling events primarily via the induction of specific protein-serine/threonine kinases. Interest in the pathway has been driven by its frequent aberrant activation in disease and its impact on cell fate decisions owing to roles in survival signaling and metabolic control. There have been recent advances in our understanding of the primary components of this pathway, namely phosphoinositide-dependent kinase-1, protein kinase B and glycogen synthase kinase-3, including insights into their mechanisms of regulation, substrate proteins and cellular functions.
磷酸肌醇3'激酶信号通路在多种生长因子和细胞因子的作用下被激活，并主要通过诱导特定的蛋白质丝氨酸/苏氨酸激酶引发一系列信号事件。由于该通路在疾病中频繁异常激活，且在生存信号传导和代谢控制中发挥作用，从而影响细胞命运决定，因此受到广泛关注。最近，我们对该通路的主要组成部分，即磷酸肌醇依赖性激酶-1、蛋白激酶B和糖原合酶激酶-3有了新的认识，包括对它们的调节机制、底物蛋白和细胞功能的深入了解。
