Gelman Laurent, Michalik Liliane, Desvergne Béatrice, Wahli Walter
Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Switzerland.
Curr Opin Cell Biol. 2005 Apr;17(2):216-22. doi: 10.1016/j.ceb.2005.02.002.
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid and glucose homeostasis, inflammation and wound healing. In addition to ligand binding, phosphorylation can also regulate PPARs; the biological effects of phosphorylation depend on the stimulus, the kinase, the PPAR isotype, the residue modified, the cell type and the promoter investigated. The study of this dual regulation mode, which allows PPARs to integrate signals conveyed by lipophilic ligands with those coming from the plasma membrane, may ultimately offer new therapeutic strategies.
过氧化物酶体增殖物激活受体（PPARs）是参与脂质和葡萄糖稳态、炎症及伤口愈合的核受体。除了配体结合外，磷酸化也可调节PPARs；磷酸化的生物学效应取决于刺激因素、激酶、PPAR亚型、修饰的残基、细胞类型以及所研究的启动子。对这种双重调节模式的研究，使PPARs能够将亲脂性配体传递的信号与来自质膜的信号整合起来，最终可能会提供新的治疗策略。
