Feige Jérôme N, Gelman Laurent, Michalik Liliane, Desvergne Béatrice, Wahli Walter
Center for Integrative Genomics, NCCR Frontiers in Genetics, Le Génopode, University of Lausanne, CH-1015 Lausanne, Switzerland.
Prog Lipid Res. 2006 Mar;45(2):120-59. doi: 10.1016/j.plipres.2005.12.002. Epub 2006 Jan 25.
Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear receptors which act as lipid sensors to modulate gene expression. As such, PPARs are implicated in major metabolic and inflammatory regulations with far-reaching medical consequences, as well as in important processes controlling cellular fate. Throughout this review, we focus on the cellular functions of these receptors. The molecular mechanisms through which PPARs regulate transcription are thoroughly addressed with particular emphasis on the latest results on corepressor and coactivator action. Their implication in cellular metabolism and in the control of the balance between cell proliferation, differentiation and survival is then reviewed. Finally, we discuss how the integration of various intra-cellular signaling pathways allows PPARs to participate to whole-body homeostasis by mediating regulatory crosstalks between organs.
过氧化物酶体增殖物激活受体（PPARs）构成了一个由三种核受体组成的家族，它们作为脂质传感器来调节基因表达。因此，PPARs参与主要的代谢和炎症调节，具有深远的医学影响，同时也参与控制细胞命运的重要过程。在本综述中，我们重点关注这些受体的细胞功能。我们将全面探讨PPARs调节转录的分子机制，特别强调关于共抑制因子和共激活因子作用的最新研究结果。随后将综述它们在细胞代谢以及细胞增殖、分化和存活平衡控制中的作用。最后，我们将讨论各种细胞内信号通路的整合如何使PPARs通过介导器官间的调节性相互作用来参与全身稳态。
