中性粒细胞、淋巴细胞和单核细胞计数、特定病因死亡率与冠心病：美国国家健康和营养检查调查一期流行病学随访研究
Counts of neutrophils, lymphocytes, and monocytes, cause-specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study.
作者信息
Gillum R F, Mussolino Michael E, Madans Jennifer H
机构信息
National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA.
出版信息
Ann Epidemiol. 2005 Apr;15(4):266-71. doi: 10.1016/j.annepidem.2004.08.009.
PURPOSE
To examine the association of elevated counts of white blood cell types with increased risk of coronary heart disease (CHD) and death.
METHODS
Data were examined from the NHANES-I Epidemiologic Follow-up Study.
RESULTS
Relative risks for death at ages 25 to 74 comparing the upper and lower tertiles of neutrophil count were: all causes 1.29 (95% CL, 1.14, 1.47), and cardiovascular causes 1.39 (95% CL, 1.15, 1.67) after adjusting for baseline risk factors.
CONCLUSIONS
The increased risk of CHD and death from all causes and cardiovascular diseases appeared to be only partially due to effects of smoking. No association was seen for lymphocytes or monocytes.
目的
研究白细胞类型计数升高与冠心病（CHD）风险增加及死亡之间的关联。
方法
数据来自国家健康和营养检查调查一期（NHANES - I）流行病学随访研究。
结果
在调整基线风险因素后，比较中性粒细胞计数高低三分位数时，25至74岁人群的全因死亡相对风险为1.29（95%可信区间，1.14，1.47），心血管疾病死亡相对风险为1.39（95%可信区间，1.15，1.67）。
结论
冠心病、全因死亡及心血管疾病风险增加似乎仅部分归因于吸烟的影响。未发现淋巴细胞或单核细胞与上述情况有关联。
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