脆性X智力低下蛋白的翻译复杂性：来自果蝇的见解。

Translational complexity of the fragile x mental retardation protein: insights from the fly.

作者信息

Broadie Kendal, Pan Luyuan

机构信息

Department of Biological Sciences, Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37232, USA.

出版信息

Mol Cell. 2005 Mar 18;17(6):757-9. doi: 10.1016/j.molcel.2005.03.004.

DOI:10.1016/j.molcel.2005.03.004

PMID:15780932

Abstract

Through the awesome power of Drosophila genetics, two recent studies reveal novel mechanisms by which the Fragile X Mental Retardation protein regulates selective mRNA translation, controlling key steps of germline development during oogenesis and neuronal development during synaptogenesis.

摘要

通过果蝇遗传学的强大力量，最近的两项研究揭示了脆性X智力低下蛋白调节选择性mRNA翻译的新机制，该机制控制着卵子发生过程中生殖系发育以及突触发生过程中神经元发育的关键步骤。