Zarnescu D C, Shan G, Warren S T, Jin P
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Genes Brain Behav. 2005 Aug;4(6):385-92. doi: 10.1111/j.1601-183X.2005.00136.x.
The past few years have seen an increased number of articles using Drosophila as a model system to study fragile X syndrome. Phenotypic analyses have demonstrated an array of neuronal and behavioral defects similar to the phenotypes reported in mouse models as well as human patients. The availability of both cellular and molecular tools along with the power of genetics makes the tiny fruit fly a premiere model in elucidating the molecular basis of fragile X syndrome. Here, we summarize the advances made in recent years in the characterization of fragile X Drosophila models and the identification of new molecular partners in neural development.
在过去几年中，使用果蝇作为模型系统来研究脆性X综合征的文章数量有所增加。表型分析已经证明了一系列神经元和行为缺陷，这些缺陷与在小鼠模型以及人类患者中报道的表型相似。细胞和分子工具的可用性以及遗传学的力量，使得这种微小的果蝇成为阐明脆性X综合征分子基础的首要模型。在这里，我们总结了近年来在脆性X果蝇模型特征描述以及神经发育中新分子伙伴鉴定方面所取得的进展。
