DiSilvestro R A, Marten J, Skehan M
Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana.
J Am Coll Nutr. 1992 Apr;11(2):177-80.
Inflammation, an acute phase stress, alters copper (Cu) metabolism, but effects on human Cu requirements are unknown. Cu supplementation (2 mg/day, 4 weeks) increased erythrocyte Cu-zinc (Zn) superoxide dismutase (SOD) activity levels in 18 of 23 rheumatoid arthritis (RA) patients receiving gold or methotrexate (mean increase 21%). SOD values were significantly lower in RA patients than in 47 age- and sex-matched controls before, but not after supplementation. Supplementation did not significantly affect ceruloplasmin (Cp) activity or protein concentrations in either group. However, RA subjects showed significantly lower Cp activity to protein ratios compared to controls, before and after supplementation. Cu supplementation did not affect acute phase status of RA patients as evidenced by unchanged serum alpha-1-acid glycoprotein levels. In conclusion, the effects of Cu supplementation on erythrocyte SOD activities suggested a trend toward marginal Cu status in RA patients.
炎症作为一种急性期应激反应，会改变铜（Cu）的代谢，但对人体铜需求的影响尚不清楚。在23名接受金制剂或甲氨蝶呤治疗的类风湿性关节炎（RA）患者中，有18名患者补充铜（每天2毫克，持续4周）后，红细胞铜锌（Zn）超氧化物歧化酶（SOD）活性水平升高（平均升高21%）。补充铜之前，RA患者的SOD值显著低于47名年龄和性别匹配的对照组，但补充后两组无显著差异。补充铜对两组患者的铜蓝蛋白（Cp）活性或蛋白浓度均无显著影响。然而，无论补充铜前后，RA患者的Cp活性与蛋白比值均显著低于对照组。血清α-1-酸性糖蛋白水平未变，表明补充铜对RA患者的急性期状态无影响。总之，补充铜对红细胞SOD活性的影响表明RA患者存在边缘性铜缺乏的趋势。
