Tungtrongchitr Rungsunn, Pongpaew Praneet, Phonrat Benjaluck, Tungtrongchitr Anchalee, Viroonudomphol Duangkamol, Vudhivai Niyomsri, Schelp Frank Peter
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
J Med Assoc Thai. 2003 Jun;86(6):543-51.
The serum copper, selenium, ceruloplasmin, superoxide dismutase (SOD) (specific activities of antioxidant enzymes), anthropometric measurements, including waist/hip ratio 51 male and 190 female overweight subjects (body mass index (BMI) > or = 25.0 kg/m2) compared with a 26 male and 83 female control group (BMI = 18.5-24.9 kg/m2) Thai volunteers who attended the Out-patient Department, General Practice Section, Rajvithi Hospital, Bangkok, for a physical check-up from March to October, 1998, were investigated. There was no age difference between the overweight group and the controls. All of the anthropometric variables, except the height of the overweight group, were significantly higher than those of the normal subjects. The medians of weight and waist/hip ratio of overweight and obese males were significantly higher than those of overweight and obese females. Serum ceruloplasmin, copper were statistically significantly higher in overweight subjects than in the controls. However, serum zinc and superoxide dismutase activity in the overweight group were found to be lower than in the control group. Higher serum ceruloplasmin, copper, zinc and superoxide dismutase activity were shown in the female overweight group than in the male overweight group. Ceruloplasmin was found to correlate positively with copper concentration but negatively related with superoxide dismutase enzyme activity. A negative correlation was found between serum copper and zinc concentrations in both sexes of the overweight and obese subjects. Low SOD activity found in the overweight and obese subjects might be caused by low zinc intake.
对1998年3月至10月期间到曼谷拉吉维蒂医院综合诊疗科门诊进行体检的泰国志愿者进行了调查。将51名男性和190名女性超重受试者（体重指数（BMI）≥25.0kg/m²）的血清铜、硒、铜蓝蛋白、超氧化物歧化酶（SOD）（抗氧化酶的比活性）、人体测量指标（包括腰臀比）与26名男性和83名女性对照组（BMI = 18.5 - 24.9kg/m²）进行比较。超重组与对照组之间不存在年龄差异。除超重组的身高外，所有人体测量变量均显著高于正常受试者。超重和肥胖男性的体重中位数和腰臀比显著高于超重和肥胖女性。超重受试者的血清铜蓝蛋白、铜在统计学上显著高于对照组。然而，发现超重组的血清锌和超氧化物歧化酶活性低于对照组。女性超重组的血清铜蓝蛋白、铜、锌和超氧化物歧化酶活性高于男性超重组。发现铜蓝蛋白与铜浓度呈正相关，但与超氧化物歧化酶活性呈负相关。在超重和肥胖受试者的男女两性中，血清铜和锌浓度之间均呈负相关。超重和肥胖受试者中发现的低SOD活性可能是由于锌摄入量低所致。
