抗坏血酸对乙醇诱导的大鼠睾丸损伤的实验性治疗干预
Experimental therapeutic intervention with ascorbic acid in ethanol induced testicular injuries in rats.
作者信息
Maneesh M, Jayalakshmi H, Dutta Sanjiba, Chakrabarti Amit, Vasudevan D M
机构信息
Department of Biochemistry, Sikkim Manipal Institute of Medicine Sciences, Gangtok, India.
出版信息
Indian J Exp Biol. 2005 Feb;43(2):172-6.
PMID:15782819
Abstract
Ascorbic acid treatment significantly increased the activities of testicular delta5, 3beta-HSD and 17beta-HSD. Moreover, the treatment was also associated with significant decrease in oxidative stress in the testis. Ethanol induced oxidative stress and decreased steroidogenesis can be reversed by treatment with ascorbic acid.
摘要
抗坏血酸处理显著提高了睾丸中Δ5, 3β-羟基类固醇脱氢酶（3β-HSD）和17β-羟基类固醇脱氢酶（17β-HSD）的活性。此外，该处理还与睾丸氧化应激的显著降低有关。乙醇诱导的氧化应激和类固醇生成减少可通过抗坏血酸处理得到逆转。
Zotero 插件