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甘露糖受体介导人类球孢子菌病中的细胞免疫反应。

The mannose receptor mediates the cellular immune response in human coccidioidomycosis.

作者信息

Ampel Neil M, Nelson Daniel K, Li Lijin, Dionne Sara O, Lake Douglas F, Simmons Keira A, Pappagianis Demosthenes

机构信息

Department of Medicine, University of Arizona Health Sciences Center, Tucson, Arizona, USA.

出版信息

Infect Immun. 2005 Apr;73(4):2554-5. doi: 10.1128/IAI.73.4.2554-2555.2005.

DOI:10.1128/IAI.73.4.2554-2555.2005
PMID:15784604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1087400/
Abstract

Mannose is the predominant monosaccharide in the coccidioidal antigen preparation T27K. Mannan and anti-CD206 antibody significantly decreased the surface expression of mannose receptor (MR) on adherent peripheral blood mononuclear cells and reduced the interleukin-2 (IL-2) release induced by T27K. These data suggest that MR mediates IL-2 release by T27K.

摘要

甘露糖是球孢子菌抗原制剂T27K中的主要单糖。甘露聚糖和抗CD206抗体显著降低了黏附性外周血单核细胞上甘露糖受体（MR）的表面表达，并减少了T27K诱导的白细胞介素-2（IL-2）释放。这些数据表明，MR介导了T27K诱导的IL-2释放。

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本文引用的文献

1
Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program.单核细胞衍生的树突状细胞上甘露糖受体的交联激活了抗炎性免疫抑制程序。
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Polysaccharide of Coccidioides immitis.粗球孢子菌多糖
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Primary dendritic cells phagocytose Cryptococcus neoformans via mannose receptors and Fcgamma receptor II for presentation to T lymphocytes.初级树突状细胞通过甘露糖受体和Fcγ受体II吞噬新型隐球菌，以呈递给T淋巴细胞。
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4
Optimal T cell responses to Cryptococcus neoformans mannoprotein are dependent on recognition of conjugated carbohydrates by mannose receptors.对新型隐球菌甘露糖蛋白的最佳T细胞反应取决于甘露糖受体对共轭碳水化合物的识别。
J Immunol. 2002 Mar 15;168(6):2872-9. doi: 10.4049/jimmunol.168.6.2872.
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Innate immune recognition.固有免疫识别
Annu Rev Immunol. 2002;20:197-216. doi: 10.1146/annurev.immunol.20.083001.084359. Epub 2001 Oct 4.
6
Assessment of the human cellular immune response to T27K, a coccidioidal antigen preparation, by flow cytometry of whole blood.通过全血流式细胞术评估人体对球孢子菌抗原制剂T27K的细胞免疫反应。
Med Mycol. 2001 Aug;39(4):315-20. doi: 10.1080/mmy.39.4.315.320.
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Flow cytometric assessment of human peripheral blood mononuclear cells in response to a coccidioidal antigen.流式细胞术评估人类外周血单个核细胞对球孢子菌抗原的反应。
Med Mycol. 2000 Apr;38(2):127-32. doi: 10.1080/mmy.38.2.127.132.
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Delayed-type hypersensitivity, in vitro T-cell responsiveness and risk of active coccidioidomycosis among HIV-infected patients living in the coccidioidal endemic area.生活在球孢子菌病流行地区的HIV感染患者的迟发型超敏反应、体外T细胞反应性及活动性球孢子菌病风险
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Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.树突状细胞利用巨胞饮作用和甘露糖受体将大分子聚集于主要组织相容性复合体II类区室：细胞因子和细菌产物的下调作用
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Unusual reducing sugar from Coccidioides immitis.来自粗球孢子菌的异常还原糖。
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