接受抗结核治疗患者的14C-尿素呼气试验
14C-urea breath test in patients undergoing anti-tuberculosis therapy.
作者信息
Mirbagheri Sayed Amir, Sohrabpour Amir Ali, Hasibi Mehrdad, Moghimi Babak, Mohamadnejad Mehdi
机构信息
Department of Gastroenterology, Amir-Alam General Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
World J Gastroenterol. 2005 Mar 21;11(11):1712-4. doi: 10.3748/wjg.v11.i11.1712.
AIM
Urea breath test (UBT) is a non-invasive diagnostic test for detecting the presence of Helicobacter pylori (H pylori). In this study we evaluated the effect of anti-tuberculosis therapy on the results of 14C-UBT.
METHODS
Patients, with the diagnosis of tuberculosis (TB) who had a positive UBT at the point of starting anti-TB therapy, were included. None had a history of peptic ulcer disease or had taken antibiotics, bismuth compounds and/or PPI in the previous month. 14C-UBT was repeated at the end of the second month and the end of treatment period and one month after completion of treatment course.
RESULTS
Thirty-five patients (23 males) were enrolled. 14C-UBT was negative in all 35 patients (100%) at the end of the second month and remained negative in 30 cases (85.7%) at the end of the treatment course. One month after completion of treatment course, UBT remained negative in 13 patients (37.1%).
CONCLUSION
Our report underscores the need for caution while interpreting urea breath test results in patients undergoing anti-TB therapy. Furthermore, the combination of drugs used in this study resulted in H pylori eradication in a minority of patients.
目的
尿素呼气试验（UBT）是一种用于检测幽门螺杆菌（H pylori）感染的非侵入性诊断测试。在本研究中，我们评估了抗结核治疗对¹⁴C-UBT结果的影响。
方法
纳入在开始抗结核治疗时UBT呈阳性的结核病（TB）患者。所有患者均无消化性溃疡病史，且在前一个月未服用过抗生素、铋剂和/或质子泵抑制剂（PPI）。在第二个月末、治疗期末以及疗程结束后1个月重复进行¹⁴C-UBT。
结果
共纳入35例患者（23例男性）。第二个月末所有35例患者（100%）的¹⁴C-UBT均为阴性，治疗期末30例（85.7%）仍为阴性。疗程结束后1个月，13例患者（37.1%）的UBT仍为阴性。
结论
我们的报告强调，在解释接受抗结核治疗患者的尿素呼气试验结果时需要谨慎。此外，本研究中使用的药物组合仅使少数患者的幽门螺杆菌得以根除。
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