Heep M, Beck D, Bayerdörffer E, Lehn N
Institut für Medizinische Mikrobiologie, Universitätsklinikum Regensburg, D-93053, Regensburg, Germany.
Antimicrob Agents Chemother. 1999 Jun;43(6):1497-9. doi: 10.1128/AAC.43.6.1497.
Eighty-one clinical isolates of Helicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 microg/ml; MIC at which 50% of isolates are inhibited [MIC50], 0.25 microg/ml). The MIC50 of rifabutin was 0.008 microg/ml (n = 16). All resistant laboratory mutants of H. pylori ATCC 43504 showed amino acid exchanges in codons 524 to 545 or codon 585 of the rpoB gene, corresponding to the gene sequences from Mycobacterium tuberculosis and Escherichia coli.
81株幽门螺杆菌临床分离株对利福平均无耐药性（最低抑菌浓度范围为0.032至2微克/毫升；50%分离株被抑制时的最低抑菌浓度[MIC50]为0.25微克/毫升）。利福布汀的MIC50为0.008微克/毫升（n = 16）。幽门螺杆菌ATCC 43504的所有耐药实验室突变株在rpoB基因的524至545密码子或585密码子处出现氨基酸交换，这与结核分枝杆菌和大肠杆菌的基因序列相对应。
