Laine L, Estrada R, Trujillo M, Knigge K, Fennerty M B
University of Southern California School of Medicine, Los Angeles 90033, USA.
Ann Intern Med. 1998 Oct 1;129(7):547-50. doi: 10.7326/0003-4819-129-7-199810010-00007.
Proton-pump inhibitor therapy may cause false-negative results on Helicobacter pylori diagnostic testing.
To determine the frequency and duration of conversion of urea breath test results from positive to negative in patients given a proton-pump inhibitor.
Two urban university gastroenterology clinics.
Patients infected with H. pylori who had positive results on urea breath tests.
Lansoprazole, 30 mg/d for 28 days.
The urea breath test was repeated at 28 days. If the results were negative, testing was repeated 3, 7, 14, and 28 days after completion of therapy until the results reverted to positive.
31 (33%) of 93 patients in whom H. pylori was not eradicated had a negative breath test result while receiving lansoprazole. The proportions of patients whose breath test results were positive after completion of lansoprazole therapy were 91% (95% CI, 83% to 96%) at 3 days, 97% (CI, 90% to 99%) at 7 days, and 100% (CI, 96% to 100%) at 14 days.
Patients should not receive proton-pump inhibitors for 2 weeks before receiving the urea breath test for H. pylori infection.
质子泵抑制剂治疗可能导致幽门螺杆菌诊断检测出现假阴性结果。
确定接受质子泵抑制剂治疗的患者尿素呼气试验结果从阳性转为阴性的频率和持续时间。
两家城市大学胃肠病诊所。
尿素呼气试验结果为阳性的幽门螺杆菌感染患者。
兰索拉唑，30毫克/天，持续28天。
在28天时重复进行尿素呼气试验。如果结果为阴性，则在治疗结束后3天、7天、14天和28天重复检测，直到结果恢复为阳性。
93例未根除幽门螺杆菌的患者中，31例（33%）在接受兰索拉唑治疗时呼气试验结果为阴性。兰索拉唑治疗结束后3天，呼气试验结果为阳性的患者比例为91%（95%CI，83%至96%）；7天时为97%（CI，90%至99%）；14天时为100%（CI，96%至100%）。
在接受幽门螺杆菌感染的尿素呼气试验前2周，患者不应接受质子泵抑制剂治疗。
