金刚烷基-OEG-富勒烯杂化物的合成与水溶性

Synthesis and water solubility of adamantyl-OEG-fullerene hybrids.

作者信息

Bar-Shir Amnon, Engel Yoni, Gozin Michael

机构信息

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

出版信息

J Org Chem. 2005 Apr 1;70(7):2660-6. doi: 10.1021/jo0479359.

DOI:10.1021/jo0479359

PMID:15787557

Abstract

[reaction: see text] A series of new adamantyl-oligoethyleneglycol-fullerene hybrids was prepared via Bingel-Hirsch functionalization of the C60 fullerene with various adamantyl-oligoethyleneglycol malonates. As NMDA-targeted antioxidants, these compounds may have the potential to be developed as therapeutic agents for the treatment of neurological disorders.

摘要

[反应：见正文] 通过用各种金刚烷基-低聚乙二醇丙二酸酯对C60富勒烯进行宾格尔-赫希官能化反应，制备了一系列新型金刚烷基-低聚乙二醇-富勒烯杂化物。作为靶向N-甲基-D-天冬氨酸（NMDA）的抗氧化剂，这些化合物有可能被开发成为治疗神经疾病的治疗药物。