Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice.
作者信息
Nakazono Manabu, Hasegawa Shigeo, Yamamoto Tsuneyuki, Zaitsu Kiyoshi
机构信息
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
出版信息
Bioorg Med Chem Lett. 2004 Nov 15;14(22):5619-21. doi: 10.1016/j.bmcl.2004.08.053.
PMID:15482935
Abstract
The 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene was synthesized from N,N'-di(1-adamantyl)malondiamide and C(60) in the presence of 1,8-diazabicyclo[5,4,0]-7-undecene. The intraperitoneal administration of this fullerene derivative (10mg/kg) caused an antagonistic effect on haloperidol-induced catalepsy in mice.
摘要
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