Roth H W, Leimbeck R, Sonnenschein B, Anger C B, Weber S
Institut für wissenschaftliche Kontaktoptik, Ulm.
Klin Monbl Augenheilkd. 1992 Mar;200(3):182-6. doi: 10.1055/s-2008-1045735.
Swabs of the anterior eye segment of 180 eyes (145 patients) taken in the time period between August 1, 1989 until August 30, 1989 were sent to an external, independent microbiological institute in order to verify in-vitro antibacterial properties of marketed sulfacetamide containing drugs. MIC test was performed with isolated pathogenic bacterial strains without knowledge of the underlying diagnosis. It was shown that sulfacetamide is able to inhibit the growth of all isolated strains. Depending on the type of bacteria concentrations of 0.006 up to 6.4% sodium sulfacetamide proved to be effective. Simultaneously, all patients were treated with sulfacetamide containing ointment and/or eye drops 4 times daily for maximum of 14 days. With swabs taken at intervals of 7 and 14 days no bacterial growth was detected.
1989年8月1日至1989年8月30日期间采集的180只眼（145例患者）眼前节拭子被送往一家外部独立微生物研究所，以验证市售含磺胺醋酰药物的体外抗菌特性。在不了解潜在诊断的情况下，对分离出的致病菌株进行了MIC试验。结果表明，磺胺醋酰能够抑制所有分离菌株的生长。根据细菌类型，0.006%至6.4%的磺胺醋酰钠浓度被证明是有效的。同时，所有患者均接受含磺胺醋酰的眼膏和/或眼药水治疗，每天4次，最长14天。在间隔7天和14天采集的拭子中未检测到细菌生长。
