年龄对视神经乳头血流的影响。

The effect of age on optic nerve head blood flow.

作者信息

Boehm Andreas G, Koeller Andrea U, Pillunat Lutz E

机构信息

Department of Ophthalmology, University of Dresden, Dresden, Germany.

出版信息

Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1291-5. doi: 10.1167/iovs.04-0987.

DOI:10.1167/iovs.04-0987

PMID:15790893

Abstract

PURPOSE

To examine whether optic nerve head blood flow changes with aging.

METHODS

One randomly chosen eye of each of 103 healthy subjects (age range, 22-76 years) was examined by laser Doppler flowmetry. Relative capillary blood flow, velocity, and volume of the moving red blood cells were measured at the temporal and nasal neuroretinal rim of the optic nerve head. For statistical analysis, linear regression analysis and partial correlations were calculated.

RESULTS

Velocity increased with age. The Pearson correlation coefficient (R) between age and velocity was 0.49 temporally and 0.56 nasally. The correlation was significantly different from 0 (both P < 0.0005). Volume decreased with increasing age. The Pearson correlation coefficient between age and volume was -0.47 temporally and -0.40 nasally. The correlation was significantly different from 0 (both P < 0.0005). Flow decreased with increasing age. The Pearson correlation coefficient between age and flow was -0.27 temporally and -0.31 nasally. The correlations were significantly different from 0 (P = 0.006 and P = 0.002, respectively). Partial correlation coefficients between the perfusion parameters and age, after correcting for systolic and diastolic blood pressure, heart rate, gender, and IOP, were similar compared to the Pearson correlation coefficients and remained statistically significant.

CONCLUSIONS

The perfusion of the optic nerve head is altered with increasing age. The results suggest that the blood supply is reduced in elderly subjects.

摘要

目的

研究视神经乳头血流是否随年龄变化。

方法

对103名健康受试者（年龄范围22 - 76岁）每人随机选取一只眼睛进行激光多普勒血流测定。测量视神经乳头颞侧和鼻侧神经视网膜边缘处相对毛细血管血流、移动红细胞的速度和体积。进行统计分析时，计算线性回归分析和偏相关。

结果

速度随年龄增加。年龄与速度之间的Pearson相关系数（R）在颞侧为0.49，在鼻侧为0.56。相关性显著不同于0（P均<0.0005）。体积随年龄增加而减小。年龄与体积之间的Pearson相关系数在颞侧为 - 0.47，在鼻侧为 - 0.40。相关性显著不同于0（P均<0.0005）。血流随年龄增加而减少。年龄与血流之间的Pearson相关系数在颞侧为 - 0.27，在鼻侧为 - 0.31。相关性显著不同于0（分别为P = 0.006和P = 0.002）。在校正收缩压、舒张压、心率、性别和眼压后，灌注参数与年龄之间的偏相关系数与Pearson相关系数相似，且仍具有统计学意义。