Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Division of Biostatistics, Clinical Research Center, Aichi Medical University, Nagakute, Aichi, Japan.
Sci Rep. 2017 Oct 24;7(1):13878. doi: 10.1038/s41598-017-14118-0.
Sex-related differences are present in the systemic and ocular blood flow. However, the cause of the sex-related differences has not been determined. We investigated the ocular blood flow, represented by the mean blur rate (MBR), on the optic nerve head (ONH) determined by laser speckle flowgraphy in 138 males (63.9 ± 8.9 years) and 194 females (63.5 ± 9.4 years). The correlations between the MBR on the ONH and the clinical data were determined. The overall ONH-MBR was significantly higher in females than males (P < 0.001). In addition, the levels of the hemoglobin and hematocrit were significantly lower in females than in males (P < 0.001). The ONH-MBR was negatively and significantly correlated with the levels of the hemoglobin and hematocrit (both, P < 0.001). Multiple regression analyses showed that the sex (β = 0.248, P < 0.001) was an independent factor correlated with the ONH-MBR when the clinical examination data were not included in the analyses. However, when the clinical examination data were included, the hemoglobin level (β = -0.295, P < 0.001) was an independent factor that contributed to the ONH-MBR but the sex was not. We conclude that the sex-related differences in the hemoglobin level and the negative correlation between hemoglobin and the ONH-MBR are the causes of the sex-related differences in the ONH-MBR.
性别与系统性和眼部血流有关。然而，导致性别差异的原因尚未确定。我们通过激光散斑血流图对 138 名男性（63.9±8.9 岁）和 194 名女性（63.5±9.4 岁）视神经头（ONH）的平均模糊率（MBR）进行了眼部血流检测，以研究 ONH 的血流情况。确定了 MBR 与临床数据之间的相关性。女性的整体 ONH-MBR 明显高于男性（P<0.001）。此外，女性的血红蛋白和血细胞比容水平明显低于男性（P<0.001）。ONH-MBR 与血红蛋白和血细胞比容水平呈负相关（均 P<0.001）。多元回归分析显示，当不包括临床检查数据进行分析时，性别（β=0.248，P<0.001）是与 ONH-MBR 相关的独立因素。然而，当包括临床检查数据时，血红蛋白水平（β=-0.295，P<0.001）是导致 ONH-MBR 的独立因素，而性别则不是。我们得出结论，血红蛋白水平的性别差异以及血红蛋白与 ONH-MBR 之间的负相关是导致 ONH-MBR 性别差异的原因。
