Muto P, Ravo V
I Servizio di Radiologia e Radioterapia, Università, Napoli.
Radiol Med. 1992 Mar;83(3):273-5.
The authors present the results obtained in 14 children affected with orbital rhabdomyosarcoma, who were studied between 1979 and 1991 at the I Dept. of Radiology and Radiotherapy of the II Policlinico, Naples, Italy. The patients (age range: 14 months to 15 years) had received radiotherapy and chemotherapy: the dose was 6000 cGy to the orbital region (one case was given 4500 cGy and then interrupted radiotherapy for personal reasons). Twelve children underwent a standard protocol, that is biopsy followed by immediate irradiation and chemotherapy; surgery was performed in 2 cases. 90% survival at 2 years was obtained in our series. All 14 patients are alive and free of detectable disease, after a minimum of 7 to a maximum of 126 months from diagnosis. In 3 children a locoregional relapse was observed 12, 15, and 16 months after clinical diagnosis. They have received a new cycle of radiation therapy and are now free of detectable disease. In all children, ocular structures have been spared, and the complications observed so far have been few. Therefore, the authors suggest that the combination of immediate radiotherapy and chemotherapy might represent an optimal tool for the treatment of orbital rhabdomyosarcomas.
作者展示了1979年至1991年间在意大利那不勒斯第二综合医院放射学与放射治疗一科对14例眼眶横纹肌肉瘤患儿的研究结果。这些患者（年龄范围：14个月至15岁）接受了放疗和化疗：眼眶区域的剂量为6000 cGy（1例因个人原因先接受了4500 cGy，然后中断放疗）。12名儿童接受了标准方案，即活检后立即进行放疗和化疗；2例接受了手术。我们的系列研究中2年生存率为90%。自诊断后至少7个月至最长126个月，所有14例患者均存活且未发现可检测到的疾病。3名儿童在临床诊断后12、15和16个月出现局部复发。他们接受了新一轮放疗，目前未发现可检测到的疾病。所有儿童的眼部结构均得以保留，目前观察到的并发症很少。因此，作者认为立即放疗和化疗相结合可能是治疗眼眶横纹肌肉瘤的最佳方法。
