Abramovitch Robert B, Martin Gregory B
Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853, USA.
FEMS Microbiol Lett. 2005 Apr 1;245(1):1-8. doi: 10.1016/j.femsle.2005.02.025.
Pseudomonas syringae pv. tomato DC3000 is a model pathogen for studying the molecular basis of plant immunity and disease susceptibility in tomato and Arabidopsis. DC3000 uses a type III secretion system to inject effector proteins into the plant cell. Type III effectors are thought to promote bacterial virulence by suppressing plant defenses and enhancing access to nutrients trapped in the plant cell. The AvrPtoB type III effector elicits immunity-associated programmed cell death (PCD) when expressed in tomato plants carrying the Pto resistance protein. However, in the absence of Pto, AvrPtoB functions to suppress PCD and immunity in tomato. Here, we review current research examining the molecular basis of AvrPtoB-mediated elicitation and suppression of plant PCD. In addition, the "trump model" is proposed to explain how resistance proteins successfully elicit immunity-associated PCD in response to effectors that suppress PCD.
丁香假单胞菌番茄致病变种DC3000是用于研究番茄和拟南芥中植物免疫和感病性分子基础的模式病原菌。DC3000利用III型分泌系统将效应蛋白注入植物细胞。III型效应蛋白被认为通过抑制植物防御和增强对植物细胞中捕获的养分的获取来促进细菌毒力。当在携带Pto抗性蛋白的番茄植株中表达时，AvrPtoB III型效应蛋白会引发与免疫相关的程序性细胞死亡（PCD）。然而，在没有Pto的情况下，AvrPtoB在番茄中发挥抑制PCD和免疫的作用。在此，我们综述了当前研究AvrPtoB介导的植物PCD激发和抑制分子基础的研究。此外，还提出了“王牌模型”来解释抗性蛋白如何成功地响应抑制PCD的效应蛋白引发与免疫相关的PCD。
