Fukuyama Mitsutoshi, Rokutan Kazuhito, Sano Toshiaki, Miyake Hidenori, Shimada Mitsuo, Tashiro Seiki
Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima 770-8503, Japan.
Cancer Lett. 2005 Apr 18;221(1):97-104. doi: 10.1016/j.canlet.2004.08.031.
A superoxide-producing enzyme, NADPH oxidase 1 (Nox1), dominantly expressed in the colon, is implicated in the pathogenesis of colon cancer. Immunohistochemistry showed that Nox1 was constitutively expressed in surface mucous cells. Adenomas and well differentiated adenocarcinomas up-regulated Nox1 expression. Ki-67-negative, well differentiated tumor cells contained abundant Nox1, whereas Ki-67-positive, proliferating cells did not express it. This differentiation-dependent expression in normal as well as tumor tissues suggests distinct roles of Nox1 besides mitogenic function. Nuclear factor (NF)-kappaB was predominantly activated in adenoma and adenocarcinoma cells expressing abundant Nox1, suggesting that Nox1 may stimulate NF-kappaB-dependent antiapoptotic pathways in colon tumors.
一种产生超氧化物的酶，即NADPH氧化酶1（Nox1），在结肠中大量表达，与结肠癌的发病机制有关。免疫组织化学显示，Nox1在表面黏液细胞中持续表达。腺瘤和高分化腺癌上调了Nox1的表达。Ki-67阴性的高分化肿瘤细胞含有丰富的Nox1，而Ki-67阳性的增殖细胞则不表达。这种在正常组织和肿瘤组织中依赖分化的表达表明，Nox1除了有促有丝分裂功能外，还有不同的作用。核因子（NF）-κB在表达丰富Nox1的腺瘤和腺癌细胞中主要被激活，这表明Nox1可能在结肠肿瘤中刺激NF-κB依赖的抗凋亡途径。
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