黑腹果蝇中程序性细胞死亡的遗传控制。

Genetic control of programmed cell death in Drosophila melanogaster.

作者信息

Cashio Peter, Lee Tom V, Bergmann Andreas

机构信息

The University of Texas, MD Anderson Cancer Center, Department of Biochemistry and Molecular Biology, The Genes and Development Graduate Program, Houston, TX 77030, USA.

出版信息

Semin Cell Dev Biol. 2005 Apr;16(2):225-35. doi: 10.1016/j.semcdb.2005.01.002.

DOI:10.1016/j.semcdb.2005.01.002

PMID:15797833

Abstract

Apoptosis is a genetically controlled form of cell death that is an important feature of animal development and homeostasis. The genes involved in the control and execution of apoptosis are conserved throughout evolution. However, the actual molecular mechanisms used by these genes vary from species to species. In this review, we focus on the genetic components of apoptosis in the fruit fly Drosophila melanogaster, and compare their mode of action to the one employed by the homologous genes in mammals. We also cover recent advances that show that apoptotic genes have a requirement in processes other than apoptosis.

摘要

细胞凋亡是一种由基因控制的细胞死亡形式，是动物发育和体内平衡的一个重要特征。参与细胞凋亡调控和执行的基因在整个进化过程中都是保守的。然而，这些基因所使用的实际分子机制因物种而异。在这篇综述中，我们聚焦于果蝇中细胞凋亡的遗传成分，并将它们的作用模式与哺乳动物中同源基因所采用的模式进行比较。我们还涵盖了最近的进展，这些进展表明凋亡基因在细胞凋亡以外的过程中也有需求。