细胞凋亡途径及其在发育中的重要性。
Pathways of apoptosis and importance in development.
作者信息
Twomey Ciara, McCarthy J V
机构信息
Signal Transduction Laboratory, Biochemistry Department, Biosciences Institute, University College Cork, Cork, Ireland.
出版信息
J Cell Mol Med. 2005 Apr-Jun;9(2):345-59. doi: 10.1111/j.1582-4934.2005.tb00360.x.
The elimination of cells by programmed cell death is a fundamental event in development where multicellular organisms regulate cell numbers or eliminate cells that are functionally redundant or potentially detrimental to the organism. The evolutionary conservation of the biochemical and genetic regulation of programmed cell death across species has allowed the genetic pathways of programmed cell death determined in lower species, such as the nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster to act as models to delineate the genetics and regulation of cell death in mammalian cells. These studies have identified cell autonomous and non-autonomous mechanisms that regulate of cell death and reveal that developmental cell death can either be a pre-determined cell fate or the consequence of insufficient cell interactions that normally promote cell survival.
通过程序性细胞死亡来清除细胞是发育过程中的一个基本事件，在多细胞生物体中，这一过程用于调节细胞数量，或清除功能冗余或可能对生物体有害的细胞。程序性细胞死亡的生化和遗传调控在物种间具有进化保守性，这使得在低等物种（如线虫秀丽隐杆线虫和果蝇黑腹果蝇）中确定的程序性细胞死亡遗传途径能够作为模型，来描绘哺乳动物细胞中细胞死亡的遗传学和调控机制。这些研究确定了调节细胞死亡的细胞自主和非自主机制，并揭示出发育性细胞死亡既可以是一种预先确定的细胞命运，也可以是正常促进细胞存活的细胞间相互作用不足的结果。
Zotero 插件