果蝇中程序性细胞死亡（凋亡）的遗传控制。
Genetic control of programmed cell death (apoptosis) in Drosophila.
作者信息
Xu Dongbin, Woodfield Sarah E, Lee Tom V, Fan Yun, Antonio Christian, Bergmann Andreas
机构信息
The University of Texas MD Anderson Cancer Center, The Genes and Development Graduate Program, Department of Biochemistry and Molecular Biology, Houston, Texas 77030, USA.
出版信息
Fly (Austin). 2009 Jan-Mar;3(1):78-90. doi: 10.4161/fly.3.1.7800. Epub 2009 Jan 8.
Abstract
Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.
摘要
程序性细胞死亡，即细胞凋亡，是一种高度保守的细胞过程，已在线虫、果蝇和哺乳动物中得到深入研究。遗传保守性、低冗余性、高通量遗传筛选的可行性以及对时空调节的凋亡反应的识别，使得黑腹果蝇成为研究细胞凋亡的理想模型。在这里，我们综述了果蝇细胞死亡途径的关键参与者，并讨论了它们在凋亡和非凋亡过程中的作用。
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