Zhang Quanbin, Li Ning, Zhao Tingting, Qi Huimin, Xu Zuhong, Li Zhien
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P.R. China.
Phytother Res. 2005 Jan;19(1):50-3. doi: 10.1002/ptr.1623.
Fucoidan, the sulphated polysaccharide extracted from brown seaweed, has various biological activities. The effect of fucoidan on the formation of proteinuria and renal functions in active Heymann nephritis was investigated in this study. Active Heymann nephritis was induced by administering brush border protein of rat proximal uriniferous tubules (FX1A). Fucoidan was administered by oral intubation to Heymann nephritis rats at three doses (50, 100 and 200 mg/kg) once daily for 4 weeks. The elevated urinary protein excretion and plasma creatinine due to the induction of Heymann nephritis were significantly reduced by fucoidan at doses of 100 and 200 mg/kg. The results indicated that fucoidan has a renoprotective effect on active Heymann nephritis and is a promising therapeutic agent for nephritis.
岩藻多糖是从褐藻中提取的硫酸化多糖，具有多种生物活性。本研究探讨了岩藻多糖对活动性海曼肾炎蛋白尿形成及肾功能的影响。通过给予大鼠近端肾小管刷状缘蛋白（FX1A）诱导活动性海曼肾炎。将岩藻多糖以三种剂量（50、100和200mg/kg）经口插管给予海曼肾炎大鼠，每日一次，持续4周。100和200mg/kg剂量的岩藻多糖显著降低了因诱导海曼肾炎而升高的尿蛋白排泄和血浆肌酐。结果表明，岩藻多糖对活动性海曼肾炎具有肾脏保护作用，是一种有前景的肾炎治疗药物。
