岩藻聚糖硫酸酯的疗法；多功能海洋聚合物。
Therapies from fucoidan; multifunctional marine polymers.
机构信息
Marinova Pty Ltd., 249 Kennedy Drive, Cambridge, Tasmania 7170, Australia.
出版信息
Mar Drugs. 2011;9(10):1731-1760. doi: 10.3390/md9101731. Epub 2011 Sep 30.
Abstract
Published research on fucoidans increased three fold between 2000 and 2010. These algal derived marine carbohydrate polymers present numerous valuable bioactivities. This review discusses the role for fucoidan in the control of acute and chronic inflammation via selectin blockade, enzyme inhibition and inhibiting the complement cascade. The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fractions of fucoidan from different sources. Recent in vivo, in vitro and clinical research related to diverse clinical needs is discussed. Targets include osteoarthritis, kidney and liver disease, neglected infectious diseases, hemopoietic stem cell modulation, protection from radiation damage and treatments for snake envenomation. In recent years, the production of well characterized reproducible fucoidan fractions on a commercial scale has become possible making therapies from fucoidan a realizable goal.
摘要
2000 年至 2010 年期间，有关褐藻胶的已发表研究增加了两倍。这些源自藻类的海洋碳水化合物聚合物具有多种有价值的生物活性。本文讨论了褐藻胶通过选择素阻断、酶抑制和抑制补体级联反应来控制急性和慢性炎症的作用。详细介绍了褐藻胶的毒理学和摄取的最新数据，并讨论了来自不同来源的褐藻胶级分的比较活性。讨论了与各种临床需求相关的最近的体内、体外和临床研究。目标包括骨关节炎、肾脏和肝脏疾病、被忽视的传染病、造血干细胞调节、辐射损伤保护以及蛇咬伤治疗。近年来，在商业规模上生产具有良好特征和可重现性的褐藻胶级分已成为可能，使褐藻胶疗法成为一个可行的目标。
相似文献
1
Therapies from fucoidan; multifunctional marine polymers.岩藻聚糖硫酸酯的疗法；多功能海洋聚合物。
Mar Drugs. 2011;9(10):1731-1760. doi: 10.3390/md9101731. Epub 2011 Sep 30.
2
Therapeutic Effects of Fucoidan: A Review on Recent Studies.褐藻糖胶的治疗效果：近期研究综述
Mar Drugs. 2019 Aug 21;17(9):487. doi: 10.3390/md17090487.
3
Review: prospects for the use of extracts and polysaccharides from marine algae to prevent and treat the diseases caused by Helicobacter pylori.综述：利用海洋藻类提取物和多糖预防和治疗幽门螺杆菌引起的疾病的前景。
Helicobacter. 2015 Apr;20(2):89-97. doi: 10.1111/hel.12177. Epub 2015 Feb 8.
4
Fucoidans and Bowel Health.褐藻胶与肠道健康。
Mar Drugs. 2021 Jul 30;19(8):436. doi: 10.3390/md19080436.
5
Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance.褐藻糖胶在癌症中的作用：对转移和耐药性的影响。
Mar Drugs. 2020 Apr 28;18(5):232. doi: 10.3390/md18050232.
6
[Antiviral action and pathogenetic targets for seaweed sulfated polysaccharides in herpesvirus infections].[海藻硫酸多糖在疱疹病毒感染中的抗病毒作用及致病靶点]
Biomed Khim. 2016 Mar;62(3):217-27. doi: 10.18097/PBMC20166203217.
7
Attenuation of N-nitrosodiethylamine-induced liver fibrosis by high-molecular-weight fucoidan derived from Cladosiphon okamuranus.冈村枝管藻来源的高分子量岩藻依聚糖对N-亚硝基二乙胺诱导的肝纤维化的抑制作用
J Gastroenterol Hepatol. 2010 Oct;25(10):1692-701. doi: 10.1111/j.1440-1746.2009.06187.x.
8
An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients.岩藻依聚糖对晚期癌症患者生活质量的抗炎作用的探索性研究。
Integr Cancer Ther. 2018 Jun;17(2):282-291. doi: 10.1177/1534735417692097. Epub 2017 Feb 12.
9
[Fucoidan: advances in the study of its anti-inflammatory and anti-oxidative effects].[岩藻依聚糖：其抗炎和抗氧化作用的研究进展]
Yao Xue Xue Bao. 2008 Dec;43(12):1186-9.
10
Fucoidan as a marine anticancer agent in preclinical development.褐藻糖胶作为一种处于临床前开发阶段的海洋抗癌药物。
Mar Drugs. 2014 Jan 28;12(2):851-70. doi: 10.3390/md12020851.
引用本文的文献
1
Special Issue "New Insights into Adipose Tissue Metabolic Function and Dysfunction, 3rd Edition".特刊《脂肪组织代谢功能与功能障碍新见解，第三版》
Int J Mol Sci. 2025 Aug 13;26(16):7831. doi: 10.3390/ijms26167831.
2
Fucoidan-Based Gold Nanoparticles: Antioxidant and Anticancer Potential from and .基于岩藻依聚糖的金纳米粒子：来自[具体来源]的抗氧化和抗癌潜力。 （你原文中“from and.”表述不太完整准确，推测可能是这样补充翻译）
Pharmaceutics. 2025 Jun 25;17(7):826. doi: 10.3390/pharmaceutics17070826.
3
Gut Microbiome Modulation and Health Benefits of a Novel Fucoidan Extract from : A Double-Blind, Placebo-Controlled Trial.新型岩藻依聚糖提取物对肠道微生物群的调节作用及其健康益处：一项双盲、安慰剂对照试验
Microorganisms. 2025 Jun 30;13(7):1545. doi: 10.3390/microorganisms13071545.
4
Characterizing Gene-Level Adaptations in the Gut Microbiome During Viral Infections: The Role of a Fucoidan-Rich Extract.表征病毒感染期间肠道微生物群中的基因水平适应性：富含岩藻依聚糖提取物的作用。
Genes (Basel). 2025 Jun 26;16(7):740. doi: 10.3390/genes16070740.
5
Nutritional Modulation of Impaired Blood-Brain Barrier Integrity and Function in Major Depression.重度抑郁症中血脑屏障完整性和功能受损的营养调节
Int J Mol Sci. 2025 Jul 18;26(14):6917. doi: 10.3390/ijms26146917.
6
From Sea to Relief: The Therapeutic Potential of Marine Algal Antioxidants in Pain Alleviation.从海洋到缓解：海洋藻类抗氧化剂在减轻疼痛方面的治疗潜力。
Mar Drugs. 2025 Jun 27;23(7):270. doi: 10.3390/md23070270.
7
Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression.作为针对自身免疫性疾病进展的聚合物纳米疗法的天然存在的多效性生物活性抗氧化化合物。
Curr Issues Mol Biol. 2025 Jun 1;47(6):411. doi: 10.3390/cimb47060411.
8
Increased Alkaline Phosphatase Associated with Brown Algae and Mushroom Extract-Containing Supplement Use.碱性磷酸酶升高与食用含褐藻和蘑菇提取物的补充剂有关。
Can Liver J. 2025 Mar 5;8(2):290-294. doi: 10.3138/canlivj-2025-0005. eCollection 2025 May.
9
Anti-Inflammatory Effects of L. Polysaccharide and Its Limited Gene Expression Profile.L.多糖的抗炎作用及其有限的基因表达谱
Int J Mol Sci. 2025 Jun 10;26(12):5562. doi: 10.3390/ijms26125562.
10
A review on the immunomodulatory properties of functional nutraceuticals as dietary interventions for children to combat COVID-19 related infections.功能性营养保健品作为儿童对抗新冠病毒相关感染的饮食干预措施的免疫调节特性综述。
Food Prod Process Nutr. 2023;5(1):17. doi: 10.1186/s43014-023-00133-4. Epub 2023 Apr 6.
本文引用的文献
1
Protective effects of fucoidan against γ-radiation-induced damage of blood cells.褐藻糖胶对γ 射线诱导血细胞损伤的保护作用。
Arch Pharm Res. 2011 Apr;34(4):645-51. doi: 10.1007/s12272-011-0415-6. Epub 2011 May 5.
2
Fucoidan cures infection with both antimony-susceptible and -resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants.岩藻聚糖硫酸酯通过 Th1 反应和巨噬细胞衍生的氧化剂治愈对锑敏感和耐药株杜氏利什曼原虫感染。
J Antimicrob Chemother. 2011 Mar;66(3):618-25. doi: 10.1093/jac/dkq502. Epub 2011 Jan 14.
3
A combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex.一项关于海藻提取物营养复合物免疫调节作用的I期和II期联合开放标签研究。
Biologics. 2011;5:45-60. doi: 10.2147/BTT.S12535. Epub 2011 Feb 15.
4
Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease.岩藻依聚糖疗法可降低1型人类嗜T淋巴细胞病毒相关神经疾病患者的前病毒载量。
Antivir Ther. 2011;16(1):89-98. doi: 10.3851/IMP1699.
5
Proteomics of wound exudate in snake venom-induced pathology: search for biomarkers to assess tissue damage and therapeutic success.蛇毒诱导病理伤口渗出物的蛋白质组学：寻找生物标志物来评估组织损伤和治疗效果。
J Proteome Res. 2011 Apr 1;10(4):1987-2005. doi: 10.1021/pr101208f. Epub 2011 Mar 2.
6
Sulfated polysaccharide fucoidan ameliorates experimental autoimmune myocarditis in rats.硫酸多糖岩藻聚糖改善大鼠实验性自身免疫性心肌炎。
J Cardiovasc Pharmacol Ther. 2011 Mar;16(1):79-86. doi: 10.1177/1074248410378751. Epub 2010 Dec 30.
7
Antiviral agents in Alzheimer's disease: hope for the future?阿尔茨海默病中的抗病毒药物：未来的希望？
Ther Adv Neurol Disord. 2010 May;3(3):141-52. doi: 10.1177/1756285610370069.
8
Biological effects of fucoidan isolated from Fucus vesiculosus on thrombosis and vascular cells.从墨角藻中分离出的岩藻依聚糖对血栓形成和血管细胞的生物学效应。
Korean J Hematol. 2010 Mar;45(1):51-7. doi: 10.5045/kjh.2010.45.1.51. Epub 2010 Mar 31.
9
Effect of heparin, fucoidan and other polysaccharides on adhesion of enterohepatic helicobacter species to murine macrophages.肝素、褐藻聚糖和其他多糖对肠肝螺杆菌属黏附于鼠源巨噬细胞的影响。
Appl Biochem Biotechnol. 2011 May;164(1):1-9. doi: 10.1007/s12010-010-9109-7. Epub 2010 Nov 19.
10
Low molecular weight fucoidan prevents intimal hyperplasia in rat injured thoracic aorta through the modulation of matrix metalloproteinase-2 expression.低相对分子质量岩藻聚糖硫酸酯通过调节基质金属蛋白酶-2 的表达来预防大鼠损伤胸主动脉内膜增生。
Biochem Pharmacol. 2011 Jan 15;81(2):233-43. doi: 10.1016/j.bcp.2010.09.021. Epub 2010 Sep 29.
Zotero 插件