Forsmo S, Oian P, Stalsberg H
Kvinneklinikken, 9012 Regionsykehuset i Tromsø.
Tidsskr Nor Laegeforen. 1992 Mar 30;112(9):1148-51.
Between 1983 and 1988, 402 women, with ages ranging from 18 to 73 years were treated for cervical intraepithelial neoplasia using the CO2-laser. 89 patients underwent vaporization and 313 conization. Preoperative biopsy examination showed CIN III in 214 patients. Five cases of invasive cancer were diagnosed, either preoperatively (two cases), after conization (two cases) or on both occasions (one case). At the first postoperative examination residual disease was found in 21 patients of the vaporization group (23.6%) and in 13 patients of the conization group (4.3%). Later examinations (after 5-70 months) revealed recurrence in 10 patients in the vaporization group (11%) and in 13 patients in the conization group (4.3%). Median time for recurrence was 11 months. 30 patients were treated twice or more. No case of invasive cancer was diagnosed after treatment.
1983年至1988年间，402名年龄在18岁至73岁之间的女性接受了二氧化碳激光治疗宫颈上皮内瘤变。89例患者接受了汽化治疗，313例接受了锥形切除术。术前活检检查显示214例患者为CIN III。诊断出5例浸润癌，其中2例为术前诊断，2例为锥形切除术后诊断，1例为两次诊断均发现。在首次术后检查中，汽化组有21例患者（23.6%）发现残留疾病，锥形切除组有13例患者（4.3%）发现残留疾病。后期检查（5至70个月后）显示，汽化组有10例患者（11%）复发，锥形切除组有13例患者（4.3%）复发。复发的中位时间为11个月。30例患者接受了两次或更多次治疗。治疗后未诊断出浸润癌病例。
