Zivin J A, Waud D R
Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla 92093-0624.
Stroke. 1992 May;23(5):767-73. doi: 10.1161/01.str.23.5.767.
Experimental investigation of stroke, in particular the evaluation of therapeutic maneuvers, is difficult because even well-controlled experiments show considerable variability. Optimal use of resources requires efficient statistical analysis.
A body of experience in pharmacology that is directly applicable to stroke studies is reviewed. The general approach, though well known to pharmacologists, is less familiar to neurologists. This paper attempts to give a survey so that neurologists encountering studies using this general class of analysis will better be able to put the technique into context. The general nature of a quantal bioassay is described, the underlying conceptual models are discussed, and specific examples are given.
The pharmacologist's approach to the analysis of quantal bioassays can easily be adapted to the quantification of results in studies of stroke.
中风的实验研究，尤其是治疗手段的评估，存在困难，因为即使是控制良好的实验也显示出相当大的变异性。资源的最佳利用需要高效的统计分析。
回顾了直接适用于中风研究的药理学经验。这种一般方法，虽然药理学家很熟悉，但神经学家不太熟悉。本文试图进行概述，以便遇到使用此类一般分析方法进行研究的神经学家能够更好地将该技术置于实际背景中。描述了定量生物测定的一般性质，讨论了潜在的概念模型，并给出了具体示例。
药理学家分析定量生物测定的方法可以很容易地适用于中风研究结果的量化。
