Guglielmi Alfredo, Fior Francesca, Halmos Orsolya, Veraldi Gian Franco, Rossaro Lorenzo, Ruzzenente Andrea, Cordiano Claudio
First Department of General Surgery, University of verona, Borgo Trento Hospital, P.le Stefani 1, 37126 Verona, Italy.
World J Gastroenterol. 2005 Apr 7;11(13):2035-8. doi: 10.3748/wjg.v11.i13.2035.
To present a case of acute mesenteric and portal vein thrombosis treated with thrombolytic therapy in a patient with ulcerative colitis in acute phase and to review the literature on thrombolytic therapy of mesenteric-portal system. Treatment of acute portal vein thrombosis has ranged from conservative treatment with thrombolysis and anticoagulation therapy to surgical treatment with thrombectomy and/or intestinal resection.
We treated our patient with intraportal infusion of plasminogen activator and then heparin through a percutaneous transhepatic catheter.
Thrombus resolved despite premature interruption of the thrombolytic treatment for neurological complications, which subsequently resolved.
Conservative management with plasminogen activator, could be considered as a good treatment for patients with acute porto-mesenteric thrombosis.
介绍1例处于急性期的溃疡性结肠炎患者采用溶栓疗法治疗急性肠系膜静脉和门静脉血栓形成的病例，并回顾有关肠系膜-门静脉系统溶栓治疗的文献。急性门静脉血栓形成的治疗方法多样，从采用溶栓和抗凝疗法的保守治疗到采用血栓切除术和/或肠切除术的手术治疗。
我们通过经皮经肝导管对患者进行门静脉内输注纤溶酶原激活剂，随后输注肝素。
尽管因神经并发症过早中断溶栓治疗，但血栓仍溶解，随后神经并发症也得到解决。
对于急性肠系膜-门静脉血栓形成的患者，使用纤溶酶原激活剂进行保守治疗可被视为一种良好的治疗方法。
