Salami M, Jira T, Otto H H
Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Germany.
Pharmazie. 2005 Mar;60(3):181-5.
The capillary zone electrophoresis using (+)-18-crown-6-tetracarbonic acid as a chiral selector was a suitable method for the enantiomeric separation of racemates of amino acids and of some amino acid derivatives (esters, dipeptides). The influence of the chemical structure of the compounds on the separation was investigated. After optimization of the separation conditions, baseline separations were obtained for most racemates. The addition of acetonitrile and TBAB yielded an improvement of the separation. Improved selectivity was further observed by the application of a cyclodextrin, HP-beta-CD, in combination with the crown ether.
使用（+）-18-冠-6-四碳酸作为手性选择剂的毛细管区带电泳是分离氨基酸及其某些氨基酸衍生物（酯、二肽）外消旋体对映体的合适方法。研究了化合物化学结构对分离的影响。在优化分离条件后，大多数外消旋体实现了基线分离。加入乙腈和四丁基溴化铵可改善分离效果。通过将环糊精HP-β-CD与冠醚联用，进一步观察到选择性得到了提高。
