Adsorptive stripping voltammetric determination of ambroxol.

An electrochemical procedure for the determination of ambroxol in mucolytics was described. The method was based on adsorptive accumulation of the species at the hanging mercury drop electrode (HMDE), followed by one of different modes of stripping sweep, viz. direct current tast (DCT), differential pulse (DP), square wave (SW) and first harmonic alternating current (AC1). The behaviour of adsorptive stripping response was studied under various experimental conditions, e.g. type of supporting electrolyte, pH, accumulation time, pulse amplitude, scan rate and mode of sweep. In Britton-Robinson buffer solution, an irreversible reduction process involving transfer of one electron and one proton was took place. The response was linear over the 0.2-6 microg/ml concentration range. Determination of the compound in oral dosage forms was achieved using the standard addition method. The average of determinations obtained by the squarewave adsorptive voltammetric method with its relative standard deviation was 99.8 +/- 2.40%.