Zayed S I M, Habib I H I
Industrial Education Faculty, Beni Suef, Egypt.
Farmaco. 2005 Jun-Jul;60(6-7):621-5. doi: 10.1016/j.farmac.2005.05.003.
The electrochemical behavior of antihistaminic drug, viz. triprolidine hydrochloride (TripCl), at a hanging mercury drop electrode (HMDE) is investigated. Chemical and electrical parameters affecting the adsorptive voltammetric measurements are optimized. Different modes of sweep, viz. direct current DC, normal pulse NP, differential pulse DP and square wave SW modes, over the potential range from -800 to -1400 mV, are used in the presence of 0.04 M Britton-Robinson buffer pH 11, with accumulation time 30 s, scan rate 50 mV/s and pulse amplitude 50 mV. The reduction process is irreversible and involved the transfer of two electrons and two protons. Their responses are linear over the concentration range 15-157 ng/ml with average correlation coefficient 0.9998, while the detection limit is 2.64, 6.24, 8.80 and 2.12 ng/ml for DC, DP, SW and NP mode, respectively. The differential pulse method has been applied successfully for the determination of the drug in Egyptian pharmaceutical preparation with mean recovery 99.55+/-0.67%.
研究了抗组胺药物盐酸曲普利啶（TripCl）在悬汞滴电极（HMDE）上的电化学行为。优化了影响吸附伏安测量的化学和电学参数。在0.04 M pH 11的 Britton-Robinson缓冲溶液存在下，采用不同的扫描模式，即直流（DC）、常规脉冲（NP）、差分脉冲（DP）和方波（SW）模式，在-800至-1400 mV的电位范围内进行扫描，积累时间为30 s，扫描速率为50 mV/s，脉冲幅度为50 mV。还原过程是不可逆的，涉及两个电子和两个质子的转移。它们的响应在15 - 157 ng/ml的浓度范围内呈线性，平均相关系数为0.9998，而直流、差分脉冲、方波和常规脉冲模式的检测限分别为2.64、6.24、8.80和2.12 ng/ml。差分脉冲法已成功应用于埃及药物制剂中该药物的测定，平均回收率为99.55±0.67%。
