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Self treatment with one of three self selected, ultramolecular homeopathic medicines for the prevention of upper respiratory tract infections in children. A double-blind randomized placebo controlled trial.使用三种自行选择的超分子顺势疗法药物之一对儿童预防上呼吸道感染进行自我治疗。一项双盲随机安慰剂对照试验。
Br J Clin Pharmacol. 2005 Apr;59(4):447-55. doi: 10.1111/j.1365-2125.2005.02336.x.
2
The use of simplified constitutional indications for self-prescription of homeopathic medicine.使用简化的体质指征进行顺势疗法药物的自我开方。
Complement Ther Med. 2004 Jun-Sep;12(2-3):112-7. doi: 10.1016/j.ctim.2004.09.004.
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An exploratory study of the contextual effect of homeopathic care. A randomised controlled trial of homeopathic care vs. self-prescribed homeopathic medicine in the prevention of upper respiratory tract infections in children.顺势疗法护理的情境效应探索性研究。顺势疗法护理与自行开具顺势疗法药物预防儿童上呼吸道感染的随机对照试验。
Prev Med. 2007 Oct;45(4):274-9; discussion 280-1. doi: 10.1016/j.ypmed.2007.02.004. Epub 2007 Feb 9.
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Complement Ther Med. 2005 Dec;13(4):231-8. doi: 10.1016/j.ctim.2005.06.007. Epub 2005 Oct 18.
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Randomized controlled trials on treatment by homeopaths and self-treatment with homeopathic medicines: design and protocol.顺势疗法医生治疗及使用顺势疗法药物自我治疗的随机对照试验：设计与方案。
J Altern Complement Med. 2004 Dec;10(6):1027-32. doi: 10.1089/acm.2004.10.1027.
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Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging study.阿司匹林与对乙酰氨基酚治疗成人发热及上呼吸道感染其他症状的比较：一项多中心、随机、双盲、双模拟、安慰剂对照、平行组、单剂量、6小时剂量范围研究。
Clin Ther. 2005 Jul;27(7):993-1003. doi: 10.1016/j.clinthera.2005.06.002.
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Homeopathic medicine for acute cough in upper respiratory tract infections and acute bronchitis: a randomized, double-blind, placebo-controlled trial.顺势疗法药物治疗上呼吸道感染和急性支气管炎的急性咳嗽：一项随机、双盲、安慰剂对照试验。
Pulm Pharmacol Ther. 2014 Feb;27(1):102-8. doi: 10.1016/j.pupt.2013.05.007. Epub 2013 May 25.
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Homeopathic medicines for prevention of influenza and acute respiratory tract infections in children: blind, randomized, placebo-controlled clinical trial.顺势疗法药物预防儿童流感和急性呼吸道感染：盲法、随机、安慰剂对照临床试验。
Homeopathy. 2016 Feb;105(1):71-7. doi: 10.1016/j.homp.2015.02.006. Epub 2015 Aug 4.
9
Do Homeopathic Pathogenetic Trials generate recognisable and reproducible symptom pictures?: Results from a pilot pathogenetic trial of Ozone 30c.顺势疗法致病试验能否产生可识别且可重复的症状图谱？：臭氧30c致病试验的初步结果。
Homeopathy. 2014 Apr;103(2):108-12. doi: 10.1016/j.homp.2013.12.001.
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Antibiotics (Basel). 2024 Jul 24;13(8):689. doi: 10.3390/antibiotics13080689.
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Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children.顺势疗法药物预防和治疗儿童急性呼吸道感染。
Cochrane Database Syst Rev. 2022 Dec 13;12(12):CD005974. doi: 10.1002/14651858.CD005974.pub6.
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Non-prescription treatments for childhood infections: an Austrian, monocentric, cross-sectional questionnaire study.非处方治疗儿童感染：奥地利单中心横断面问卷调查研究。
BMC Pediatr. 2022 Mar 24;22(1):154. doi: 10.1186/s12887-022-03220-6.
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Ital J Pediatr. 2021 Oct 25;47(1):211. doi: 10.1186/s13052-021-01150-0.
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Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects.随机临床试验中的安慰剂反应与效应：聚焦背景效应的元研究
Trials. 2021 Jul 26;22(1):493. doi: 10.1186/s13063-021-05454-8.
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Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children.用于预防和治疗儿童急性呼吸道感染的顺势疗法药品。
Cochrane Database Syst Rev. 2018 Sep 9;9(9):CD005974. doi: 10.1002/14651858.CD005974.pub5.
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Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children.用于预防和治疗儿童急性呼吸道感染的顺势疗法药品。
Cochrane Database Syst Rev. 2018 Apr 9;4(4):CD005974. doi: 10.1002/14651858.CD005974.pub4.
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Oral Astragalus (Huang qi) for preventing frequent episodes of acute respiratory tract infection in children.口服黄芪预防儿童急性呼吸道感染频繁发作
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The Effectiveness and Safety of a Homeopathic Medicinal Product in Pediatric Upper Respiratory Tract Infections With Fever: A Randomized Controlled Trial.顺势疗法药物治疗小儿上呼吸道感染伴发热的有效性和安全性：一项随机对照试验
Glob Pediatr Health. 2016 Jul 4;3:2333794X16654851. doi: 10.1177/2333794X16654851. eCollection 2016.
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Effectiveness, safety and tolerability of a complex homeopathic medicinal product in the prevention of recurrent acute upper respiratory tract infections in children: a multicenter, open, comparative, randomized, controlled clinical trial.一种复方顺势疗法药品预防儿童复发性急性上呼吸道感染的有效性、安全性及耐受性：一项多中心、开放、比较、随机、对照临床试验
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本文引用的文献

1
The use of simplified constitutional indications for self-prescription of homeopathic medicine.使用简化的体质指征进行顺势疗法药物的自我开方。
Complement Ther Med. 2004 Jun-Sep;12(2-3):112-7. doi: 10.1016/j.ctim.2004.09.004.
2
Users of homeopaths in Norway in 1998, compared to previous users and GP patients.1998年挪威顺势疗法使用者与之前的使用者及全科医生患者的比较。
Homeopathy. 2003 Jan;92(1):3-10. doi: 10.1054/homp.2002.0068.
3
A survey of the use of over-the-counter homeopathic medicines purchased in health stores in central Manchester.对在曼彻斯特市中心健康商店购买的非处方顺势疗法药物的使用情况调查。
Homeopathy. 2002 Oct;91(4):225-9. doi: 10.1054/homp.2002.0053.
4
Homeopathic constitutional type questionnaire correlates of conventional psychological and physical health scales: individual difference characteristics of young adults.顺势疗法体质类型问卷与传统心理和身体健康量表的相关性：年轻人的个体差异特征
Homeopathy. 2002 Apr;91(2):63-74. doi: 10.1054/homp.2002.0003.
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Blackie Memorial Lecture 2001. Homeopathy: progress and promise, a critical perspective.2001年布莱基纪念讲座。顺势疗法：进展与前景，批判性视角。
Br Homeopath J. 2001 Oct;90(4):204-13. doi: 10.1054/homp.1999.0514.
6
The Constitutional Type Questionnaire: validation in the patient population of the Royal London Homoeopathic Hospital.体质类型问卷：在伦敦皇家顺势疗法医院患者群体中的验证
Br Homeopath J. 2001 Jul;90(3):131-7. doi: 10.1054/homp.1999.0493.
7
[Nasal congestion and earache--upper respiratory tract infections in 4-year-old children].[鼻塞和耳痛——4岁儿童的上呼吸道感染]
Tidsskr Nor Laegeforen. 2001 Apr 30;121(11):1329-32.
8
Homeopathic treatment of acute otitis media in children: a preliminary randomized placebo-controlled trial.顺势疗法治疗儿童急性中耳炎：一项初步随机安慰剂对照试验。
Pediatr Infect Dis J. 2001 Feb;20(2):177-83. doi: 10.1097/00006454-200102000-00012.
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Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media.儿童急性中耳炎两种处方策略的实用性随机对照试验
BMJ. 2001 Feb 10;322(7282):336-42. doi: 10.1136/bmj.322.7282.336.
10
Do homeopathic medicines provoke adverse effects? A systematic review.顺势疗法药物会引发不良反应吗？一项系统评价。
Br Homeopath J. 2000 Jul;89 Suppl 1:S35-8. doi: 10.1054/homp.1999.0378.

使用三种自行选择的超分子顺势疗法药物之一对儿童预防上呼吸道感染进行自我治疗。一项双盲随机安慰剂对照试验。

Self treatment with one of three self selected, ultramolecular homeopathic medicines for the prevention of upper respiratory tract infections in children. A double-blind randomized placebo controlled trial.

作者信息

Steinsbekk Aslak, Bentzen Niels, Fønnebø Vinjar, Lewith George

机构信息

Department of Public Health and General Practice, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

出版信息

Br J Clin Pharmacol. 2005 Apr;59(4):447-55. doi: 10.1111/j.1365-2125.2005.02336.x.

DOI:10.1111/j.1365-2125.2005.02336.x
PMID:15801940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1884806/
Abstract

AIMS

Homeopathic medicines are frequently purchased over the counter (OTC). Respiratory complaints are the most frequent reason for such purchases. Children with upper respiratory tract infection (URTI) are frequent users of homeopathy. This study investigates the effect of self treatment with one of three self selected ultramolecular homeopathic medicines for the prevention of childhood URTI.

METHODS

A double-blind randomized parallel group placebo controlled trial was carried out in 251 children below the age of 10 years, recruited by post from those previously diagnosed with URTI when attending a casualty department. The children were randomly assigned to receive either placebo or ultramolecular homeopathic medicines in C-30 potency (diluted 10(-60)) administered twice weekly for 12 weeks. Parents chose the medicine based on simplified constitutional indications for the three medicines most frequently prescribed by Norwegian homeopaths for this group of patients. The main outcome measure relates to the prevention of new episodes of URTI measured with median total symptom score over 12 weeks.

RESULTS

There was no difference in the predefined primary outcome between the two groups (P = 0.733). Median URTI scores over 12 weeks in the homeopathic medicine group were 26.0 (95% confidence interval (CI) 16.3, 43.7) and for placebo 25.0 (95% CI 14.2, 38.4). There was no statistical difference between the two groups in median number of days with URTI symptoms or in the use of conventional medication/care.

CONCLUSIONS

In this study there was no effect over placebo for self treatment with one of three self selected, ultramolecular homeopathic medicines in preventing childhood URTI. This can be due to the lack of effect of the highly diluted homeopathic medicines or the process of selection and type of medicines.

摘要

目的

顺势疗法药物经常在柜台购买。呼吸道疾病是购买此类药物的最常见原因。患有上呼吸道感染（URTI）的儿童是顺势疗法的频繁使用者。本研究调查了三种自行选择的超分子顺势疗法药物之一进行自我治疗对预防儿童URTI的效果。

方法

对251名10岁以下儿童进行了一项双盲随机平行组安慰剂对照试验，这些儿童是通过邮寄从之前在急诊科就诊时被诊断为URTI的儿童中招募的。儿童被随机分配接受安慰剂或C-30效力（稀释10（-60））的超分子顺势疗法药物，每周服用两次，共12周。家长根据挪威顺势疗法医生针对该组患者最常开的三种药物的简化体质指标选择药物。主要结局指标涉及通过12周内的总症状评分中位数来衡量的预防URTI新发作情况。

结果

两组之间预先定义的主要结局没有差异（P = 0.733）。顺势疗法药物组12周内URTI评分中位数为26.0（95%置信区间（CI）16.3，43.7），安慰剂组为25.0（95%CI 14.2，38.4）。两组在URTI症状天数中位数或使用传统药物/护理方面没有统计学差异。

结论

在本研究中，三种自行选择的超分子顺势疗法药物之一进行自我治疗在预防儿童URTI方面对安慰剂没有效果。这可能是由于高度稀释的顺势疗法药物缺乏效果，或者是药物的选择过程和类型所致。