PII 信号转导蛋白：调节氮代谢的α-酮戊二酸传感器。
PII signal transduction proteins: sensors of alpha-ketoglutarate that regulate nitrogen metabolism.
作者信息
Ninfa Alexander J, Jiang Peng
机构信息
Department of Biological Chemistry, University of Michigan Medical School, 1301 E. Catherine St., Ann Arbor, Michigan 48109-0606, USA.
出版信息
Curr Opin Microbiol. 2005 Apr;8(2):168-73. doi: 10.1016/j.mib.2005.02.011.
PMID:15802248
Abstract
PII proteins are small homotrimeric signal transduction proteins that regulate the activities of metabolic enzymes and permeases, and control the activities of signal transduction enzymes. The protein family shows high conservation, with examples in eukaryota (plants and eukaryotic algae), archaea, and bacteria. This distribution indicates that PII is one of the most ancient signalling proteins known.
摘要
PII蛋白是小型同三聚体信号转导蛋白，可调节代谢酶和通透酶的活性，并控制信号转导酶的活性。该蛋白家族具有高度保守性，在真核生物（植物和真核藻类）、古细菌和细菌中均有实例。这种分布表明PII是已知最古老的信号蛋白之一。
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