Commichau Fabian M, Forchhammer Karl, Stülke Jörg
Department of General Microbiology, Institute of Microbiology and Genetics, Georg-August University Göttingen, Grisebachstr. 8, D-37077 Göttingen, Germany.
Curr Opin Microbiol. 2006 Apr;9(2):167-72. doi: 10.1016/j.mib.2006.01.001. Epub 2006 Feb 2.
The metabolism of carbon- and nitrogen-containing compounds is fundamental to all forms of life. To cope with changing environmental conditions, bacteria have to sense the nutrient supply and adapt their metabolism accordingly. In addition to nutrient- and pathway-specific responses, they integrate information from the different branches of metabolism to coordinate the control of the expression of many metabolic genes. Two major players interconnecting carbon and nitrogen regulation are the PII proteins and the phosphotransferase system. Moreover, several DNA-binding transcription regulators sense signals are derived from both carbon and nitrogen metabolism. The regulatory networks enable the bacteria to make the appropriate metabolic responses to changing nutrient availabilities in the environment.
含碳和含氮化合物的代谢是所有生命形式的基础。为了应对不断变化的环境条件，细菌必须感知营养供应并相应地调整其代谢。除了针对营养物质和特定途径的反应外，它们还整合来自代谢不同分支的信息，以协调对许多代谢基因表达的控制。连接碳和氮调节的两个主要参与者是PII蛋白和磷酸转移酶系统。此外，几种DNA结合转录调节因子可感知来自碳和氮代谢的信号。这些调节网络使细菌能够对环境中不断变化的营养可用性做出适当的代谢反应。
