Terai Hiromu, Tamura Nobushige, Yuasa Sadatoshi, Nakamura Tatsuo, Shimizu Yasuhiko, Komeda Masashi
Department of Thoracic and Cardiovascular Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan.
J Vasc Interv Radiol. 2005 Apr;16(4):515-9. doi: 10.1097/01.RVI.0000151142.80319.85.
To create an experimental model of aortic dissection with a long-lasting patent false lumen as a proper animal model for development of less-invasive treatment for aortic dissection.
Fifteen adult beagle dogs (weight, 10-12 kg) were used. The descending aorta was exposed by a left thoracotomy at the sixth intercostal space. The entry for the aortic dissection was created surgically just distal to the origin of the left innominate artery and the reentry was 5 cm distal to the entry point. Normal saline solution was injected into the aortic wall (ie, media) between these two points to create the dissection. The dogs were followed up at 1 day, 3 months, 1 year, and 2 years.
All 12 surviving dogs had completely patent true and false lumina without any thrombi. Microscopic examination showed that the dissection was created in the tunica media layer, making it identical to aortic dissection in humans. Color Doppler imaging confirmed the patency of the true and false lumina and the relatively narrowed true lumen.
In this canine model of aortic dissection, the false lumen has excellent long-term patency and the dissection plane is histologically similar to that in human aortic dissection. This model may contribute to the development of new treatments for Stanford type B aortic dissection.
创建一种主动脉夹层实验模型，其假腔长期通畅，作为开发主动脉夹层微创治疗方法的合适动物模型。
使用15只成年比格犬（体重10 - 12千克）。通过在第六肋间进行左胸廓切开术暴露降主动脉。在左无名动脉起始部远端手术创建主动脉夹层的入口，再入口在入口点远端5厘米处。将生理盐水注入这两点之间的主动脉壁（即中膜）以形成夹层。对犬进行1天、3个月、1年和2年的随访。
所有12只存活犬的真腔和假腔均完全通畅，无任何血栓形成。显微镜检查显示夹层形成于中膜层，与人类主动脉夹层相同。彩色多普勒成像证实了真腔和假腔的通畅以及真腔相对狭窄。
在这种犬主动脉夹层模型中，假腔具有良好的长期通畅性，且夹层平面在组织学上与人类主动脉夹层相似。该模型可能有助于开发斯坦福B型主动脉夹层的新治疗方法。
