用于人类主动脉夹层研究的实验与模型：前景与挑战
Experimental and models for the study of human aortic dissection: promises and challenges.
作者信息
Jiang Ding-Sheng, Yi Xin, Zhu Xue-Hai, Wei Xiang
机构信息
Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China.
Department of Cardiology, Renmin Hospital of Wuhan UniversityWuhan 430060, China; Cardiovascular Research Institute, Wuhan UniversityWuhan 430060, China.
出版信息
Am J Transl Res. 2016 Dec 15;8(12):5125-5140. eCollection 2016.
Abstract
Aortic dissection (AD) is a life-threatening aortopathy with high mortality. To mimic spontaneous AD, investigate the pathogenesis of AD and develop novel therapeutic targets and measures, multiple AD experimental models have been generated, including drugs or chemicals induced experimental models, genetically modified experimental models, surgically or invasively induced experimental models, and models. However, the perfect model of AD that replicates every aspect of the natural disease has not be generated yet. This review provides an overview of the experimental models used in AD preclinical research. The value and challenges of each and model are discussed.
摘要
主动脉夹层（AD）是一种具有高死亡率的危及生命的主动脉疾病。为了模拟自发性AD、研究AD的发病机制并开发新的治疗靶点和措施，已建立了多种AD实验模型，包括药物或化学物质诱导的实验模型、基因修饰实验模型、手术或侵入性诱导实验模型以及 模型。然而，尚未产生能够复制自然疾病各个方面的完美AD模型。本综述概述了AD临床前研究中使用的实验模型。讨论了每种 和 模型的价值和挑战。
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