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阻塞性睡眠呼吸暂停患者中合并睡眠障碍的患病率。

Prevalence of concomitant sleep disorders in patients with obstructive sleep apnea.

作者信息

Scharf Steven M, Tubman Abby, Smale Patricia

机构信息

Division of Pulmonary and Critical Care Medicine, University of Maryland Sleep Disorders Center, Baltimore, MD 21201, USA.

出版信息

Sleep Breath. 2005 Jun;9(2):50-6. doi: 10.1007/s11325-005-0014-1.

Abstract

We determined the prevalence of concomitant sleep disorders in patients with a primary diagnosis of obstructive sleep apnea (OSA). We retrospectively analyzed 643 patients, aged > or =18, with a primary diagnosis of OSA, evaluated by sleep specialists, in whom clinical and polysomnographic data were derived using standardized techniques by reviewing data from a standardized database and clinical charts. Concomitant sleep disorders were listed according to the International Classification of Sleep Disorders (American Academy of Sleep Medicine, 2000). The mean age was 48.5+/-13.5 years and 55% were male. Racial distributions were African-Americans 51.8% and Caucasian 47%. Indices of disordered breathing were respiratory disturbance index 32.4+/-30.4/h sleep and time <90% O(2) saturation 44.5+/-81.6 min. Thirty-one percent of patients had a concomitant sleep disorder. The most common were inadequate sleep hygiene (14.5%) and periodic limb movement disorder (PLMD, 8.1%). Of patients with other sleep disorders, 66.8% had treatment initiated for these disorders. Predictors of inadequate sleep hygiene (logistic regression) were: age (each decade OR=0.678, P=0.000000), gender (for M, OR=0.536), and the presence of at least one other major system disorder (OR=2.123, P=0.0015). Predictors of PLMD were: age (each decade OR=0.794, P=0.0005), gender (for M, OR=0.433, P=0.004), and total sleep time (for each 10 min, OR=0.972, P=0.0013). We conclude that approximately one third of patients with sleep apnea have another identifiable sleep disorder, usually requiring treatment. This suggests that practitioners evaluating and treating sleep apnea ought to be prepared to deal with other sleep disorders as well.

摘要

我们确定了以阻塞性睡眠呼吸暂停(OSA)为主要诊断的患者中合并睡眠障碍的患病率。我们回顾性分析了643例年龄≥18岁、以OSA为主要诊断的患者,这些患者由睡眠专家进行评估,通过查阅标准化数据库和临床图表中的数据,使用标准化技术获取临床和多导睡眠图数据。根据《国际睡眠障碍分类》(美国睡眠医学学会,2000年)列出合并的睡眠障碍。平均年龄为48.5±13.5岁,55%为男性。种族分布为非裔美国人51.8%,白种人47%。呼吸紊乱指标为呼吸紊乱指数32.4±30.4次/小时睡眠,血氧饱和度<90%的时间为44.5±81.6分钟。31%的患者合并有睡眠障碍。最常见的是睡眠卫生不良(14.5%)和周期性肢体运动障碍(PLMD,8.1%)。在患有其他睡眠障碍的患者中,66.8%的患者针对这些障碍开始了治疗。睡眠卫生不良的预测因素(逻辑回归)为:年龄(每增加十岁,OR=0.678,P=0.000000)、性别(男性,OR=0.536)以及至少存在一种其他主要系统疾病(OR=2.123,P=0.0015)。PLMD的预测因素为:年龄(每增加十岁,OR=0.794,P=0.0005)、性别(男性,OR=0.433,P=0.004)以及总睡眠时间(每增加10分钟,OR=0.972,P=0.0013)。我们得出结论,大约三分之一的睡眠呼吸暂停患者患有另一种可识别的睡眠障碍,通常需要治疗。这表明评估和治疗睡眠呼吸暂停的从业者也应该准备好应对其他睡眠障碍。

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